Alterations in lipid incorporation in Duchenne muscular dystrophy: Studies of fresh and cultured muscle |
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| Authors: | V. Ionasescu L. Monaco A. Sandra R. Ionasescu L. Burmeister C. Deprosse L.Z. Stern |
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| Affiliation: | 1. Department of Pediatrics, Medical School, University of Iowa, Iowa City, IA 52242 U.S.A.;2. Department of Anatomy, Medical School, University of Iowa, Iowa City, IA 52242 U.S.A.;3. Department of Biostatistics, Medical School, University of Iowa, Iowa City, IA 52242 U.S.A.;4. Department of Obstetrics and Gynecology, Medical School, University of Iowa, Iowa City, IA 52242 U.S.A.;5. Department of Neurology, University of Arizona, Tucson, AZ U.S.A. |
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| Abstract: | The incorporation of [3H]glycerol into lipids of fresh and cultured skeletal muscle obtained from patients with Duchenne muscular dystrophy (DMD), patients with myotonic dystrophy (My Dyst), controls, and aborted fetuses (10–12 weeks old) was studied. A significant increase of specific incorporation of [3H]glycerol into phosphatidylcholine (PCh), phosphatidylserine (PS), phosphatidylinositol (PI), and triglycerides (TRI) was found in DMD and fetal muscle in both fresh and cultured muscle. No significant differences, however, were noted between the values of glycerol incorporation in DMD and fetal muscle. The ratio between phospholipids and TRI changed significantly for fresh muscle in DMD (3.5) and fetal muscle (4.9) versus controls (24). The incorporation of glycerol into these lipids in My Dyst fresh and cultured muscle showed the same values as controls when expressed both as incorporation/mg protein and ratio between phospholipids and TRI. |
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| Keywords: | Reprint requests to: V. Ionasescu M.D. Department of Pediatrics University of Iowa Hospitals Iowa City IA 52242 U.S.A. |
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