Erythrocyte membrane in myotonic dystrophy: A study with acetylcholinesterase |
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Authors: | Hideki Igisu Yasunobu Antoku Shiro Mawatari Yoshigoro Kuroiwa |
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Affiliation: | 1. Institute of Health Science and Department of Neurology, Faculty of Medicine, Kyushu University, Fukuoka 812 Japan;2. National Akasaka Hospital and Department of Neurology, Faculty of Medicine, Kyushu University, Fukuoka 812 Japan;3. Health Administration Center, Kyushu Institute of Technology, Kyushu University, Fukuoka 812 Japan;4. Department of Neurology, Faculty of Medicine, Kyushu University, Fukuoka 812 Japan |
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Abstract: | Erythrocyte membrane in myotonic dystrophy (MyD) was studied with respect to acetylcholinesterase (AchE), an enzyme localized on the external surface of the membrane. The activity was determined over the temperature range of 7–41 °C (in hemolysates) and 25–41 °C (in ghosts). The activity, the transition temperature in the Arrhenius plots, and the activation energy either above or below the transition temperature did not differ between MyD and controls. The Hill coefficient for the inhibition by fluoride was approximately 1 in MyD and in controls at 13, 25 and 37°C. The dose of fluoride for 50% inhibition of the enzyme activity differed between different temperatures but not between MyD and controls. There seems to be no gross abnormality in AchE or its environment in erythrocyte membrane in MyD. |
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Keywords: | Correspondence: Hideki Igisu M.D. Department of Neurology Faculty of Medicine Kyushu University 60 Fukuoka 812 Japan. |
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