C反应蛋白水平在COPD病人、IHD病人，吸烟者和非吸烟者中的比较研究

目的评价在COPD病人中IHD症状和吸烟对CRP升高的潜在影响，并检验糖皮质激素（ICS）药物治疗与CRP血清水平之间的联系。方法对46名COPD患者与对照组的18名吸烟者（Smoking）和20名不吸烟者（N．Smoking）进行比较。结果COPD病人的CRP血清水平[4．83±1．23mg／L]显著高于两个对照组，具有显著性差异（P〈0．05），但是CRP血清水平在两个对照组中却无统计学意义。ICS治疗后，COPD病人的CRP水平降低。结论对COPD病人使用ICS治疗能够降低CRP水平。CRP可以作为COPD患者体内组织炎症的标志物。

A comparative study on C-reactive protein among patients with COPD,IHD,smokers and nonsmokers

Objective To evaluate IHD and smoking as potential causes of elevated CRP in COPD and to test the association between inhaled corticosteroids(ICS)use and serum CRP levels.Methods Cross-sectional analyses were conducted in comparing cohorts of 46 COPD patients with 18 smokers(S)and 20 non-smoker(NS)controls.Clinical assessments included a complete medical history,pulmonary function,6-minute walking test(6MWT)and high-sensitivity serum CRP.Results Serum CRP levels were significantly higher in the COPD patients [4.83(1.23)mg/L] than in the controls(P<0.05)but were similar in both control groups [S:2.13(1.06 mg/L)and NS:2.34(1.04)mg/L].CRP levels were lower in the COPD patients treated with ICS [3.18(2.7)mg/L vs 5.87(2.9)].Conclusion CRP levels were elevated in COPD patients without clinically relevant IHD,independent of cigarette smoking.CRP is reduced in COPD patients using ICS.We conclude that CRP may be a systemic marker of the inflammatory process that occurs in patients with COPD.