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| 神经营养因子前体研究进展 | |
| 引用本文： | 邓兴力,雷德强,刘如恩,冯忠堂. 神经营养因子前体研究进展[J]. 医学综述, 2008, 14(6): 806-808 |
| 作者姓名： | 邓兴力 雷德强 刘如恩 冯忠堂 |
| 作者单位： | 1. 昆明医学院第一附属医院神经外科,昆明,650032 2. 华中科技大学同济医学院附属协和医院神经外科,武汉,430022 3. 中日友好医院神经外科,北京,100029 |
| 摘 要： | 神经营养因子以其前体形式合成,在各种蛋白酶的作用下裂解为成熟蛋白。成熟的神经营养因子通过作用于Trk酪氨酸激酶受体促进神经细胞的存活和分化。最近研究表明,神经营养因子前体具有与神经营养因子相互拮抗的生物学活性,其通过作用于p75NTR受体诱导细胞凋亡。对于神经营养因子功能的新的认识,有助于更加深刻的理解其在各种细胞过程中的作用。 |
| 关 键 词： | 神经营养因子前体 分泌 凋亡 |
| 文章编号： | 1006-2084(2008)06-0806-03 |
| 修稿时间： | 2007-09-14 |
Recent Progress in the Precursor of Neurotrophins |
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| DENG Xing-li,LEI De-qiang,LIU Ru-en,FENG Zhong-tang. Recent Progress in the Precursor of Neurotrophins[J]. Medical Recapitulate, 2008, 14(6): 806-808 | |
| Authors: | DENG Xing-li LEI De-qiang LIU Ru-en FENG Zhong-tang |
| Affiliation: | DENG Xing-li1,LEI De-qiang2,LIU Ru-en3,FENG Zhong-tang1.(1.Department of Neurosurgery,the First Affiliated Hospital of Kunming Medical College,Kunming 650032,China,2.Department of Neurosurgery,United Hospital,Tongji Medical Colloge,Huazhong University of Science Technology,Wuhan 430022,3.Department of Neurosurgury,China-Japan Friendship Hospital,Beijing 100029,China.) |
| Abstract: | Neurotrophins are initially synthesized as precursors,then cleaved into mature proteins,which promote neuronal survival by activating Trk receptor tyrosine kinases.Recent studies indicate that the precursor of neurotrophins has biological effects agaist their mature neurotrophins by interacting with the p75 neurotrophin receptor(p75NTR).Therefore,the proteolytic cleavage of the precursor of neurotrophins represents a mechanism that controls the direction of action of neurotrophins.New insights into the dual... |
| Keywords: | Proneurotrophin Secretion Apoptosis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |