三七通舒联合恩必普治疗急性脑梗死血液流变学及动力学的影响

目的探讨三七通舒联合恩必普治疗急性脑梗死(acute cerebral infarct,ACI)血液流变学及动力学的影响。方法选择2017年6月-2018年8月就诊的98例ACI患者作为研究对象。按照就诊顺序将患者随机分为治疗组和对照组,两组均为49例,其中对照组给予安慰剂治疗,治疗组给予三七通舒胶囊联合恩必普治疗。研究组49例,男28例,女21例,对照组49例,男32例,女17例。比较两组患者综合疗效;国立卫生研究院脑卒中量表:神经功能缺损程度评分(NIHSS);全血高切黏度、全血低切黏度、红细胞比积(PCV)及纤维蛋白原(FIB)等血液流变学指标水平;大脑中动脉血流速度(VMCA);高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、甘油三酯(TG)及总胆固醇(TC)含量;Barthel指数(BI)评分。结果两组患者年龄、性别等一般资料无显著性差异,不具有统计学意义(P>0.05);治疗后两组患者综合疗效有统计学意义,且治疗组总有效率明显高于对照组(P<0.05);两组患者治疗后NIHSS评分较治疗前均显著下降,且治疗组下降更明显;两组患者治疗后全血高切黏度、全血低切黏度、FIB和PCV较治疗前均显著降低,且治疗组下降更明显(P<0.05);两组患者治疗后VMCA较治疗前均明显升高,且治疗组上升更明显(P<0.05);两组患者治疗后HDL含量较治疗前均明显升高,且治疗组上升更明显(P<0.05);两组患者治疗后LDL、TG、TC含量较治疗前均明显降低,且治疗组下降更明显(P<0.05);两组患者治疗后BI评分较治疗前均明显升高,且治疗组上升更明显,差异具有统计学意义(P<0.05)。结论三七通舒联合恩必普可有效改善ACI患者神经损伤程度,降低血液黏度及纤维蛋白原水平,改善体内血脂水平,防止血栓形成,提高患者预后质量,且安全性高,具有临床应用价值。

Effects of Sanqi Tongshu Capsule and Butylphthalide on Hemorheology and Kinetics in Patients with Acute Cerebral Infarction

Objective To investigate effects of Sanqi Tongshu Capsule and butylphthalide on hemorheology and kinetics in patients with acute cerebral infarction.Methods Ninety-eight patients with acute cerebral infarction admitted to neurology department from June 2017 to August 2018 were selected and divided into two groups,each with 49 cases.The control group,including 32 males and 17 female,received the placebo.Based on this,the study group,including 28 males and 21 females,received Sanqi Tongshu Capsule combined with butylphthalide.Then various indexes were compared between group,including clinical efficacy,National Institutes of Health Stroke Scale score(NIHSS),whole blood high shear viscosity,whole blood low shear viscosity,Packed Cell Volume(PCV),fibrinogen(FIB),velocity of middle cerebral artery(VMCA),high density lipoprotein(HDL),low density lipoprotein(LDL),triglyceride(TG)and total cholesterol(TC)levelsas well as the Barthel index(BI).Results The general data had no difference between the two groups(P>0.05).The total effective rate of the treatment group was significantly higher than that of the control group(P<0.05).The NIHSS scores were decreased in both groups after treatment,and were lower in the study group than those in the control group(P<0.05).The whole blood high shear viscosity,whole blood low shear viscosity,FIB and PVC were decreased in both groups after treatment,and were lower in the study group than those in the control group(P<0.05).The VMCA and HDL were increased in both groups after treatment,and were higher in the study group than those in the control group(P<0.05).The levels of LDL,TG and TC were decreased after treatment in both groups,and were higher in the study group than those in the control group(P<0.05).Conclusion The application of Sanqi Tongshu Capsule and butylphthalide is an effective and safe way to ameliorate the nerve damage degree,blood lipid levelsand prognosis,prevent thrombosisas well as reduce the blood viscosity and fibrinogen levels in patients with acute cerebral infarction.