Neoadjuvant therapy for resectable pancreatic ductal adenocarcinoma: The need for patient-centered research |
| |
Authors: | Jordan M Cloyd Allan Tsung John Hays Celia E Wills John FP Bridges |
| |
Affiliation: | Jordan M Cloyd, Allan Tsung, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210, United StatesJohn Hays, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, United StatesCelia E Wills, College of Nursing, The Ohio State University, Columbus, OH 43210, United StatesJohn FP Bridges, Department of Biomedical Informatics, The Ohio State University, Columbus, OH 43210, United States |
| |
Abstract: | Pancreatic ductal adenocarcinoma is an aggressive cancer with high recurrence rates following surgical resection. While adjuvant chemotherapy improves survival, a significant proportion of patients are unable to initiate or complete all intended therapy following pancreatectomy due to postoperative complications or poor performance status. The administration of chemotherapy prior to surgical resection is an alternative strategy that ensures its early and near universal delivery as well as improves margin-negative resection rates and potentially improves long-term survival outcomes. Neoadjuvant therapy is increasingly being recommended to patients with pancreatic ductal adenocarcinoma,however, patient-centered research on its use is lacking. In this review, we highlight opportunities to focus research efforts in the domains of patient preferences, patient-reported outcomes, patient experience, and survivorship.Novel research in these areas may identify relevant barriers and facilitators to the use of neoadjuvant therapy thereby increasing its utilization, improve shareddecision making for patients and providers, and optimize the experience of those undergoing neoadjuvant therapy. |
| |
Keywords: | Preoperative therapy Pancreatic ductal adenocarcinoma Quality of life Shared decision making Patient preferences |
本文献已被 CNKI 维普 等数据库收录! |
| 点击此处可从《World journal of gastroenterology : WJG》浏览原始摘要信息 |
|