复方红豆杉胶囊辅助治疗对卵巢癌术后化疗外周血T淋巴细胞亚群、血管内皮生长因子的影响

目的探究复方红豆杉胶囊辅助治疗对卵巢癌术后化疗患者外周血T淋巴细胞亚群、血管内皮生长因子(VEGF)的影响。方法选取2017年1月-2018年12月医院收治的卵巢癌患者200例,按随机数字表法分为对照组和观察组各100例。两组术后均给予紫杉醇+顺铂化疗方案,观察组在此基础上给予复方红豆杉胶囊治疗,两组均连续治疗4个周期。统计两组治疗4个周期后的临床疗效;检测两组治疗前和治疗4个周期后外周血T淋巴细胞亚群水平、VEGF水平;统计两组治疗4个周期后的不良反应发生情况。结果观察组和对照组的临床总缓解率分别为70.00%(70/100)、49.00%(49/100),观察组的总缓解率显著大于观察组(P<0.01)。治疗4个周期后,两组的T淋巴细胞群水平经比较有差异(P<0.01)。观察组CD+3、CD+4、CD+4/CD+8T淋巴细胞比值均升高,且均高于对照组(P<0.01),对照组CD+8T淋巴细胞显著高于对照组(P<0.01)。治疗4个周期后,两组VGEF水平均显著下降(P<0.05),且观察组小于对照组(P<0.01)。观察组患者发生胃肠道反应、血小板减少率以及白细胞减少率均显著少于对照组(P<0.05)。结论复方红豆杉胶囊辅助治疗卵巢癌术后化疗患者,可以调节外周血T淋巴细胞亚群水平,降低VEGF水平,提高临床疗效,值得临床推广应用。

Effect of Adjuvant Therapy with Compound Taxus Capsule on T Lymphocyte Subsets and Vascular Endothelial Growth Factor in Peripheral Blood of Patients with Ovarian Cancer after Chemotherapy

Objective To explore the effect of Compound Taxus Capsule on T lymphocyte subsets and vascular endothelial growth factor(VEGF) in peripheral blood of patients with ovarian cancer after chemotherapy.Methods A total of 200 patients with ovarian cancer admitted to our hospital from January 2017 to December 2018 were randomly divided into control group and observation group with 100 patients in each group. Paclitaxel combined with cisplatin chemotherapy was given to both groups after operation, and Compound Taxus Capsule was given to the observation group on the basis of the chemotherapy. Both groups were treated for 4 cycles continuously. The clinical efficacy of the two groups after 4 cycles of treatment was counted. The levels of T lymphocyte subsets and vascular endothelial growth factor in peripheral blood of the two groups before and after 4 cycles treatment were detected and the adverse reactions of the two groups after 4 cycles of treatment were counted.Results The total clinical remission rates of the observation group and the control group were 70.00% and 49.00%, respectively. The total remission rates of the observation group were significantly higher than those of the control group(P<0.05). After 4 cycles of treatment, there were differences in T lymphocyte group levels between the two groups.(P<0.01). The ratio of CD+3, CD+4 and CD+4/CD+8T lymphocyte in the observation group was higher than that in the control group(P<0.01), and the ratio of CD+8T lymphocyte in the control group was significantly higher than that in the control group(P<0.01). After 4 cycles treatment, the levels of VGEF in both groups decreased significantly(P<0.01), and the observation group’s was smaller than that of the control group(P<0.01).The incidences of gastrointestinal reactions, thrombocytopenia and leukopenia in the observation group were significantly lower than those in the control group(P<0.01).Conclusion Compound Taxus Capsule can regulate the levels of T lymphocyte subsets in peripheral blood, reduce the level of vascular endothelial growth factor and improve the clinical efficacy in the adjuvant treatment of ovarian cancer patients undergoing chemotherapy after operation, which is worthy of clinical application.