| 雷公藤生殖毒性机制研究进展 |
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| 引用本文： | 孟天琦,马宏博.雷公藤生殖毒性机制研究进展[J].中华中医药学刊,2020(3):196-198. |
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| 作者姓名： | 孟天琦 马宏博 |
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| 作者单位： | 山东中医药大学第一临床医学院;山东大学附属省立医院 |
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| 基金项目： | 国家中医药管理局“李克勤全国名老中医药专家传承工作室”建设项目(国中医药办人教函[2018]134);国家中医药管理局第四批全国中医(临床、基础)优秀人才研修项目(国中医药人教发[2017]24)。 |
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| 摘 要： | 雷公藤作为一种可靠的免疫抑制剂广泛应用于临床,其疗效肯定,但不良反应颇多。女性患者在临床治疗过程中常出现月经不调、闭经等症状,雷公藤的生殖毒性损害卵巢功能使卵泡闭锁影响女性正常内分泌水平导致闭经。对雷公藤生殖毒性方面的有关文献进行分析加以综述,探究雷公藤生殖毒性机制的研究进展,为雷公藤的进一步药理研究和妇科临床应用提供参考。
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| 关 键 词： | 雷公藤 生殖毒性 闭经 卵巢抑制 可逆性 |
Research Progress of Reproductive Toxicity Mechanism of Tripterygium wilfordii |
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| MENG Tianqi,MA Hongbo.Research Progress of Reproductive Toxicity Mechanism of Tripterygium wilfordii[J].Chinese Archives of Traditional Chinese Medicine,2020(3):196-198. |
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| Authors: | MENG Tianqi MA Hongbo |
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| Institution: | (The First Clinical Medicine College,Shandong University of Traditional Chinese Medicine,Jinan 250014,Shandong,China;Shandong Provincial Hospital Affiliated to Shandong University,Jinan 250021,Shandong,China) |
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| Abstract: | Tripterygium wilfordii is widely used as a reliable immunosuppressive agent with certain curative effect in clinical practice, while the toxic and side effects of Tripterygium wilfordii is quiet a lot. Female patients often have symptoms such as irregular menstruation and amenorrhea during clinical treatment. The reproductive toxicity of Tripterygium wilfordii damages ovarian function causing follicular atresia to affect normal endocrine level in women leading to amenorrhea. This article summarizes the literature on reproductive toxicity of Tripterygium wilfordii to explore the research progress of reproductive toxicity mechanism of Tripterygium wilfordii and provide a reference for further pharmacological research and clinical application of gynecology. |
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| Keywords: | Tripterygium wilfordii reproduction toxicity amenorrhea ovarian suppression reversibility |
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