CONFORMATION OF DISULFIDE BRIDGES IN PEPTIDES WITH PEPSIN PARTIAL SEQUENCES

On the basis of Raman spectra investigation of two model heterodetic cyclic peptides, containing partial sequences of pepsin fragments 45–50 and 206–210 of the chain, it was concluded that the disulfide bridge conformation in pepsin is determined not only by the size and conformation of the peptide loops created by disulfide bridges, but also by the peptide fragments located outside these loops.