| 星点设计-效应面法优选促孕颗粒提取工艺 |
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| 引用本文： | 陀海燕,罗纳新,谭栀恩,曾佩琴,韦艳萍,罗春花,刘雅婷,覃柳馨,陈卫卫,傅鹏. 星点设计-效应面法优选促孕颗粒提取工艺[J]. 中华中医药学刊, 2020, 0(3): 252-255,I0032 |
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| 作者姓名： | 陀海燕 罗纳新 谭栀恩 曾佩琴 韦艳萍 罗春花 刘雅婷 覃柳馨 陈卫卫 傅鹏 |
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| 作者单位： | 广西中医药大学;广西中医药大学第一附属医院;广西中药制剂共性技术研发重点实验室;广西壮瑶药重点实验室 |
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| 基金项目： | 广西一流学科中药学民族药学项目(桂教科研〔2018〕12号);广西壮瑶医药与医养结合人才小高地项目(中共广西区委厅发[2017]44号);广西中药制剂共性技术研发重点实验室项目(70-ZJGX201706);中国-东盟传统医药发展研究中心项目(J201402701);壮瑶药协同创新中心项目(桂教科研[2013]20号);广西壮瑶药重点实验室项目(桂科基字[2014]32号);广西重点学科壮药学项目(桂教科研[2013]16号);八桂学者中药创新理论与药效研究(桂科政字[2013]25号)。 |
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| 摘 要： | 目的采用星点设计-效应面法优选促孕颗粒提取工艺。方法以加水倍数、提取时间为考察因素,总评"归一值"(包括莫诺苷、马钱苷含量及干膏率)为考察指标,采用星点设计2因素5水平表安排试验,进行多元线性回归及二项式拟合,用效应面法选取提取工艺并对结果进行预测分析。结果最佳的提取工艺条件为:加15倍量水煎煮2次,每次128 min,总评"归一值"0.9319,与预测值(0.8210)偏差在-20%内。结论优选的促孕颗粒提取工艺简便,具有良好、可靠的预测性。
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| 关 键 词： | 促孕颗粒 莫诺苷 马钱苷 提取工艺 星点设计 效应面法 |
Optimization of Extraction Technology for Cuyun Granules by Central Composite Design-Response Surface Methodology |
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| TUO Haiyan,LUO Naxin,TAN Zhien,ZENG Peiqin,WEI Yanping,LUO Chunhua,LIU Yating,QIN Liuxin,CHEN Weiwei,FU Peng. Optimization of Extraction Technology for Cuyun Granules by Central Composite Design-Response Surface Methodology[J]. Chinese Archives of Traditional Chinese Medicine, 2020, 0(3): 252-255,I0032 |
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| Authors: | TUO Haiyan LUO Naxin TAN Zhien ZENG Peiqin WEI Yanping LUO Chunhua LIU Yating QIN Liuxin CHEN Weiwei FU Peng |
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| Affiliation: | (Guangxi University of Chinese Medicine,Nanning 530001,Guangxi,China;The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530001,Guangxi,China;Key Laboratory for Common Technology Research and Development of Traditional Chinese Medicine Preparations in Guangxi,Nanning 530001,Guangxi,China;Guangxi Zhuang-Yao Medicine Key Laboratory,Nanning 530001,Guangxi,China) |
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| Abstract: | Objective To optimize the extraction technology for Cuyun Granules by Central Composite Design-Response Surface Methodology.Methods Extraction technology of Cuyun Granules was optimized by taking water volume and extraction time as factors, overall desirability value of dry extract yield and the content of morroniside and loganin as evaluation indexes.Central composite designwas adopted to design a two factors-five levels table and conduct multiple linear regression and multivariate binomial fit, and then the optimal technical conditions were chosen and estimated by response surface methodology. Results The optimal technologyextraction conditionswere: extracted twice with 15-folds of water, 128 min per time. The 0.931 9 overall desirability value was within-20% from the predicted value(0.821 0).Conclusion Optimized extraction technology of Cuyun Granules was convenient with good and reliable predictability. |
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| Keywords: | Cuyun Granules morroniside loganin extraction technology central composite design response surface methodology |
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