益肺Ⅱ号方对支气管哮喘缓解期免疫功能和血清炎症因子的影响

目的观察益肺Ⅱ号方对支气管哮喘缓解期患者免疫功能和血清炎症因子的影响。方法选择2017年2月-2018年11月在医院进行治疗的支气管哮喘缓解期患者132例,根据随机分组法分为研究组和对照组,每组66例。对照组给予常规西药治疗,每日吸入沙美特罗氟替卡松粉吸入剂。研究组在对照组治疗的基础上,口服益肺Ⅱ号方治疗。7 d为1个疗程,两组均治疗4个疗程。比较两组治疗疗效,治疗前后中医症候积分,比较两组治疗前后肺功能情况,比较两组治疗前后炎症因子水平和免疫指标变化。结果研究组患者治疗总有效率为93.94%(62/66)高于对照组治疗总有效率的81.82%(54/66)(P<0.05);研究组治疗后胸闷、咳嗽、喘息和哮鸣音等临床症状积分低于对照组(P<0.05);研究组治疗后肺功能指标FVC、PEF、FEV1、FEV1/FVC优于对照组(P<0.05);研究组治疗后血清炎症因子IL-10水平高于对照组,IL-12、IL-17、Hs-CRP水平低于对照组(P<0.05);研究组治疗后免疫球蛋白IgA、IgG水平高于对照组(P<0.05)。结论益肺Ⅱ号方治疗支气管哮喘缓解期疗效确切,可有效改善临床症状,降低中医症候积分,改善肺功能,抑制气道炎症反应,提高机体免疫力,和西药常规联合应用,可提高治疗疗效。

Effect of Yifei II Recipe on Immune Function and Serum Inflammatory Factors in Patients with Bronchial Asthma in Remission Stage

Objective To observe the effect of Yifei II Recipe on immune function and serum inflammatory factors in patients with bronchial asthma in the remission stage. Methods A total of 132 patients with bronchial asthma in the remission stage who were treated in hospital from February 2017 to November 2018 were randomly divided into the studygroup and the control group, 66 cases in each group. The control group was given routine western medicine treatment, daily inhalation of salmeterol and fluticasone powder inhalation. On the basis of the treatment of the control group, the study group was treated with Yifei II Recipe orally. Seven days was a course of treatment and both groups were treated for four courses. The curative effect of the two groups were compared. The scores of TCM symptoms before and after treatment were compared. The pulmonary function before and after treatment was compared, and the levels of inflammatory factors and immune indexes before and after treatment were compared between the two groups. Results The total effective rate of the study group was 93.94%(62/66),higher than that of the control group81.82%(54/66)](P<0.05).The scores of clinical symptoms such as chest tightness, cough, wheezing and wheezing in the study group were lower than those in the control group(P<0.05).The indexes of pulmonary function in the study group were better than those in the control group(FVC, PEF, FEV1, FEV1/FVC)(P<0.05). The serum inflammatory factor IL-1 in the study group was better than that in the control group(P<0.05). The levels of IL-12, IL-17 and Hs-CRP in the study group were higher than those in the control group(P<0.05), and the levels of IgA and IgG in the study group were higher than those in the control group(P<0.05). Conclusion Yifei II Recipe is effective on treating bronchial asthma in the remission stage. It can effectively improve clinical symptoms and lung function, reduce TCM syndrome score and airway inflammation response, improve body immunityand promote the therapeutic effectcombined with routine western medicine.