温针灸联合加味当归芍药散治疗多囊卵巢综合征效果及对卵巢功能、性激素水平的影响

目的分析温针灸联合自拟加味当归芍药散治疗多囊卵巢综合征(PCOS)的效果及对卵巢功能、性激素水平的影响。方法选取2016年1月-2018年1月收治的PCOS患者108例,其中54例采用温针灸治疗(对照组),其余54例采用温针灸联合自拟加味当归芍药散治疗(观察组),分析两组患者治疗后的临床效果。结果观察组患者子宫内膜厚度较对照组厚,优势卵泡率较对照组高(P<0.05)。治疗前,两组患者性激素、血管紧张素Ⅱ、肝细胞生长因子(HGF)、β-内啡肽、非对称性二甲基精氨酸(ADMA)水平比较,差异无统计学意义(P>0.05)。治疗后,观察组患者黄体生成素/卵泡刺激素(LH/FSH)、睾酮(T)、β-内啡肽水平高于对照组,雌二醇(E2)、血管紧张素Ⅱ、HGF、ADMA水平低于对照组,(P<0.05)。治疗前,两组患者卵巢动脉血流动力学指标水平比较,差异无统计学意义(P>0.05)。治疗后,观察组患者卵巢动脉血流阻力指数(RI)水平高于对照组,卵巢动脉收缩期最大血流速度(PSV)、血流搏动指数(PI)水平低于对照组(P<0.05)。结论温针灸联合自拟加味当归芍药散治疗PCOS效果较好,可改善患者卵巢功能,降低血清性激素水平,其作用机制可能与降低血管紧张素Ⅱ、HGF、ADMA水平有关。

Effects of Warming Needle Moxibustion Combined with Modified Danggui Shaoyao Powder on Ovary Function and Sex Hormone Level in Patients with Polycystic Ovary Syndrome

Objective To analyze the effect of warming needle moxibustion combined with Modified Danggui Shaoyao Powder on ovarian function and sex hormone level in patients with polycystic ovary syndrome(PCOS). Methods From January 2016 to January 2018, 108 patients with PCOS were selected. Fifty-four cases were treated with warm acupuncture and moxibustion(control group), the other 54 cases were treated with warming acupuncture combined with Modified Danggui Shaoyao Powder(observation group). The clinical effects of the two groups were analyzed. Results The endometrial thickness was thicker and the dominant follicle rate was higher in the observation group than those in the control group(P<0.05). Before treatment, the levels of sex hormone, angiotensin Ⅱ, hepatocyte growth factor(HGF), β-endorphin and asymmetric dimethyl arginine(ADMA) were not significantly different between the two groups(P>0.05). After treatment, the levels of luteinizing hormone/follicle stimulating hormone(LH/FSH), testosterone(T), β-endorphin, estradiol(E2), angiotensin Ⅱ and HGF and ADMA in the observation group were lower than those in the control group(P<0.05). Before treatment, there was no significant difference in the level of ovarian artery hemodynamics between the two groups(P>0.05). After treatment, the blood flow resistance index(RI) of the ovarian artery in the observation group was higher than that of the control group, and the PI level of the maximal flow velocity of the ovarian artery during the period of contraction was lower than that of the control group(P<0.05). Conclusion Warming needle moxibustion combined with Self-Modified Danggui Shaoyao Powder can improve the ovarian function of PCOS patients and decrease the level of serum sex hormone. The mechanism may be related to the decrease of ADMA level of angiotensin Ⅱ and HGF.