| 桂郁金的活性成分姜黄素对抑郁症作用机制研究进展 |
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| 引用本文： | 傅品悦,钟静,梁明坤,赵铁建.桂郁金的活性成分姜黄素对抑郁症作用机制研究进展[J].中华中医药学刊,2020(3):160-163. |
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| 作者姓名： | 傅品悦 钟静 梁明坤 赵铁建 |
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| 作者单位： | 广西中医药大学研究生院;广西中医药大学基础医学院;广西中医药大学附属瑞康医院 |
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| 基金项目： | 国家自然科学基金(81660705);广西自然科学基金(2017GXNSFBA198196);广西高校引进海外高层次人才“百人计划”;广西中医药大学研究生教育创新计划(YJS201710). |
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| 摘 要： | 抑郁症(Depression)是一种严重的广泛的精神疾患,影响到全世界约17%的人,其特征是普遍或持续的精神障碍,导致情绪、认知和记忆缺陷。桂郁金的主要成分姜黄素通过多种机制治疗抑郁症,主要在抑郁症动物模型、神经递质、神经保护和抗氧化,免疫以及炎症等途径在各种动物和人类研究中都有体现。对姜黄素的抗抑郁作用的几种机制进行简要综述,为指导临床药物研发提供理论依据。
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| 关 键 词： | 桂郁金 姜黄素 抑郁症 研究进展 |
The Main Component of Cinnamon,Curcumin in Depressive Disorders: An Overview of Potential Mechanism of Action |
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| FU Pinyue,ZHONG Jing,LIANG Mingkun,ZHAO Tiejian.The Main Component of Cinnamon,Curcumin in Depressive Disorders: An Overview of Potential Mechanism of Action[J].Chinese Archives of Traditional Chinese Medicine,2020(3):160-163. |
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| Authors: | FU Pinyue ZHONG Jing LIANG Mingkun ZHAO Tiejian |
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| Institution: | (Department of Postgraduate,Guangxi University of Traditional Chinese Medicine,Nanning,530200,Guangxi,China;School of Basic Medical Sciences,Guangxi University of Traditional Chinese Medicine,Nanning 530200,Guangxi,China;Ruikang Hospital Affiliatedto Guangxi University of Traditional Chinese Medicine,Nanning 530200,Guangxi,China) |
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| Abstract: | Depression is a dysthymia disorder characterized by a pervasive or persistent mental disorder that causes mood, cognitive and memory,deficits.The main components of cinnamon is Curcumin,which may have antidepressant activities with diverse mechanisms of action involving animals model,primarily neurotransmitters, inflammatory and immune pathways, as demonstrated in various animal and human studies. This paper reviews the research status of several mechanisms of curcumin’s antidepressant effect,providing a theoretical basis for clinical research and development of new antidepressant drugs. |
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| Keywords: | cinnamon curcumin depression research progress |
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