益肾活血安胎方在子宫动脉血流异常致复发性流产治疗中的应用价值及对妊娠结局的影响

目的探讨益肾活血安胎方在子宫动脉血流异常致复发性流产患者治疗中的应用价值及对患者妊娠结局的影响。方法医院收治的子宫动脉血流异常致复发性流产患者100例,随机分为两组,各50例。对照组给予常规治疗,治疗组在对照组基础上口服益肾活血安胎方,两组患者接受治疗2个月。对比治疗后的治疗有效率、阴道出血、下腹坠胀痛、腰酸痛、肛门坠胀等症状改善情况、于孕37~40 d, 52~55 d和67~70 d孕妇S/D和RI值、妊娠结局情况和不良反应发生率。结果治疗组治疗有效率显著高于对照组(P<0.05);在治疗前,两组患者阴道出血、腰酸痛、下腹坠胀痛和肛门坠胀积分差异无统计学意义(P>0.05);经过治疗后,两组患者阴道出血、腰酸痛、下腹坠胀痛和肛门坠胀积分显著降低(P<0.05);且治疗组阴道出血、腰酸痛、下腹坠胀痛和肛门坠胀积分显著低于对照组(P<0.05);两组患者在孕37~40 d,52~55 d和67~70 d子宫动脉血流RI及S/D水平显著降低(P<0.05);并且治疗组在孕37~40 d,52~55 d和67~70 d子宫动脉血流RI及S/D水平显著低于对照组(P<0.05);治疗组自然流产率24.00%(12/50)]显著低于对照组42.00%(21/50)](P<0.05);治疗组12周活胎率72.00%(36/50)]显著高于对照组48.00(24/50)](P<0.05);在治疗前,两组患者D-二聚体和APTT水平差异无统计学意义(P>0.05);经过治疗后,治疗患者D-二聚体水平显著低于对照组,治疗组患者APTT水平显著高于对照组(P<0.05)。结论采用益肾活血安胎方用于治疗子宫动脉血流异常致复发性流产,取得了较好的治疗效果,能够降低RI及S/D水平,改善患者临床症状,值得在临床上推广应用。

Application Value of Yishen Huoxue Antai Formulain Treatment of Recurrent Abortion Caused by Abnormal Uterine Artery Blood Flow and Its Effect on Pregnancy Outcome

Objective To explore the application value of Yishen Huoxue Antai Formula in the treatment of recurrent abortion caused by abnormal uterine artery blood flow and its influence on the pregnancy outcome.Methods A total of 100 cases of recurrent abortion caused by abnormal uterine artery blood flow were randomly divided into two groups, 50 cases in each.The control group was given routine treatment, and the treatment group was given Yishen Huoxue Antai Formulaorally on the basis of the control group. The patients in the two groups received treatment for 2 months.After treatment, the treatment efficiency, vaginal bleeding, lower abdominal swelling pain, waist painanal swelling and other symptoms were compared, and the S/D and RI values, pregnancy outcome and adverse reaction rate of pregnant women on 37~40 d, 52~55 d and 67~70 d were compared.Results The effective rates of the treatment group was significantly higher than that of the control group(P<0.05).Before treatment, there were no statistically significant differences between the two groups in vaginal bleeding, waist pain, lower abdominal tumbledown pain or anal tumbleup score(P>0.05).After treatment, the scores of vaginal bleeding, waist pain, lower abdominal bulge pain and anal bulge were significantly reduced in the two groups(P<0.05).In addition, the vaginal bleeding, waist pain, lower abdominal tumbledown pain and anal tumbleup score in the treatment group were significantly lower than those in the control group(P<0.05).The levels of RI and S/D in uterine artery of the two groups were significantly decreased at 37~40 d, 52~55 d and 67~70 d(P<0.05).In addition, the levels of RI and S/D in uterine artery of the treatment group were significantly lower than those of the control group(P<0.05) on the 37~40 d, 52~55 d and 67~70 d of pregnancy.The spontaneous abortion rate of the treatment group24.00%(12/50)] was significantly lower than that of the control group42.00%(21/50)](P<0.05).The 12-week survival rate72.00%(36/50)] in the treatment group was significantly higher than that in the control group48.00%(24/50)](P<0.05).Before treatment, there was no significant difference in d-dimer and APTT levels between the two groups(P>0.05).After treatment, the level of d-dimer in the treatment group was significantly lower than that in the control group, and the APTT level in the treatment group was significantly higher than that in the control group(P<0.05).Conclusion Yishen Huoxue Antai Formula is used for the treatment of recurrent abortion caused by abnormal uterine artery blood flow, which has achieved good therapeutic effects, and can reduce the levels of RI and S/D and improve the clinical symptoms of patients. It is worthy of clinical application.