醒脑静注射液配合纳洛酮对急诊内科昏迷患者神经功能及炎性因子的影响

目的探讨醒脑静注射液配合纳洛酮治疗急诊内科昏迷的临床效果。方法将92例昏迷患者以随机数字表法分为对照组46例,观察组46例,两组均给予对症治疗,对照组加用纳洛酮,观察组在对照组基础上给予醒脑静注射液。观察两组患者用药后昏迷持续时间,治疗前、治疗2周后意识障碍程度、神经功能、炎性因子水平及不良反应发生情况。结果观察组患者用药后昏迷持续时间与对照组对比,明显较短(P<0.05);治疗前,两组意识障碍程度、神经功能及炎性因子水平均无明显差异(P>0.05),治疗2周后,观察组格拉斯哥昏迷量表(GCS)评分、昏迷恢复量表修订版(CRS-R)评分明显高于对照组,加拿大神经功量表(CNS)评分、美国国立卫生研究院卒中量表(NIHSS)评分明显低于对照组,血清超敏-C反应蛋白(hs-CRP)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平明显低于对照组(P<0.05);不良反应发生率观察组为13.04%,与对照组10.87%对比,无明显差异(P>0.05)。结论醒脑静注射液配合纳洛酮治疗急诊内科昏迷,可有效缩短患者觉醒时间,改善患者意识状态及神经功能,减轻炎症反应,且具有较高安全性,值得推广。

Effect of Xingnaojing Injection Combined with Naloxone on Neurological Function and Inflammatory Factors in Patients with Emergency Internal Medicinecoma

Objective To investigate the clinical effect of Xingnaojing Injection combined with naloxone in the treatment of emergency internal medicinecoma.Method Ninety-two patients admitted to the emergency internal medicine were randomly divided into the control group(46 cases)and the observation group(46 cases).Both groups were given symptomatic treatment.The control group added naloxone and the observation group was given Xingnaojing Injection on the basis of the control group.We observed the duration of coma after treatment,the degree of consciousness,neurological function,inflammatory factor levels before and two weeks after treatment,and the adverse reactions of two groups.Result The duration of coma after treatment in the observation group was significantly shorter compared with that of the control group(P<0.05).Before treatment,there was no significant difference in the degree of consciousness,neurological function or inflammatory factors between the two groups(P>0.05).After 2 weeks treatment,the glasgow coma scale(GCS)score and the coma recovery scale-revised(CRS-R)score in the observation group were significantly higher compared with those of the control group(P<0.05).The canadian neurological scale(CNS)score and the NIH stroke scale(NIHSS)score in the observation group were significantly lower compared with those of the control group(P<0.05).The serum hypersensitive C-reactive protein(hs-CRP),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in the observation group were significantly lower compared with those of the control group(P<0.05).Conclusion Xingnaojing Injection combined with naloxone in the treatment of emergency internal medicinecoma can effectively shorten the patients’awakening time,improve the patients’state of consciousness and nerve function,reduce inflammation and has high safety,worthy of promoting.