心脉隆注射液结合硝普钠对冠心病慢性心力衰竭患者hs-CRP、CysC以及NT-proBNP水平的影响

目的探讨心脉隆注射液结合硝普钠对冠心病慢性心力衰竭患者hs-CRP、CysC以及NT-proBNP水平的影响。方法选择2016年4月—2018年5月医院收治的冠心病慢性心力衰竭患者120例,根据随机表格法两组患者分为研究组和对照组,每组60例。对照组患者采用硝普钠治疗,研究组在对照组治疗的基础上,添加心脉隆注射液治疗。两组患者连续治疗2周。比较两组治疗后临床疗效,比较两组治疗前后心力衰竭积分、中医症候积分和生活质量评分比较,比较两组治疗前后心功能指标,比较两组治疗前后血清hs-CRP、CysC和NT-proBNP水平,比较两组治疗过程中发生的不良反应。结果研究组治疗总有效率为88.33%(53/60),显著高于对照组治疗总有效率的73.33%(44/60)(P<0.05);研究组治疗后心力衰竭积分、中医症候积分和生活质量评分低于对照组(P<0.05);研究组治疗后LVEF和VE/VA水平高于对照组,LVEDD和Tci指数水平低于对照组(P<0.05);研究组治疗后血清hs-CRP、CysC和NT-proBNP水平低于对照组(P<0.05);研究组不良反应发生率低于对照组(P<0.05)。结论心脉隆注射液治疗冠心病慢性心功能衰竭疗效确切,可有效的改善患者的临床症状,降低血浆NT-proBNP水平,抑制炎症反应,改善心功能,和硝普钠联合应用,可提高治疗效果,值得临床推广应用。

Effects of Xinmailong Injection Combined with Sodium Nitroprusside on Levels of hs-CRP,CysC and NT-proBNP in Patients with Chronic Heart Failure of Coronary Heart Disease

Objective To investigate the effects of Xinmailong Injection combined with sodium nitroprusside on the levels of hs-CRP,CysC and NT-proBNP in patients with chronic heart failure of coronary heart disease.Methods Totally 120 patients with chronic heart failure of coronary heart disease were selected from April 2016 to May 2018 in our hospital.According to the random table method,the two groups were divided into study group and control group,60 cases in each group.The patients in the control group were treated with sodium nitroprusside and those in the study group were treated with Xinmailong Injection on the basis of the treatment in the control group.Two groupswere treated continuously for 2 weeks.The clinical treatment after treatment was compared between the two groups.Heart failure score,TCM symptom score and quality of life improvement before and after treatment were compared between the two groups.Cardiac function indexes before and after treatment were compared between the two groups.Serum levels of hs-CRP,CysC and NT-proBNP were compared between the two groups before and after treatment.Adverse reactions during treatment were compared between the two groups.Results The total effective rate of the study group was 88.33%(53/60),significantly higher than 73.33%(44/60)of the control group(P<0.05).The scores of heart failure,TCM symptoms and quality of life in the study group were lower than those in the control group(P<0.05).The levels of LVEF and VE/VA in the study group were higher than those in the control group,and the levels of LVEDD and Tci index in the study group were lower than those in the control group(P<0.05).The serum levels of hs-CRP,CysC and NT-proBNP were lower in the study group than those in the control group(P<0.05)and the incidence of adverse reactions in the study group was lower than that in the control group(P<0.05).Conclusion Xinmailong Injection is effective on treating chronic heart failure of coronary heart disease.It can effectively improve clinical symptoms,reduce plasma NT-proBNP level,inhibit inflammation and improve cardiac function.Combined with sodium nitroprusside,it can improve the therapeutic effect and is worthy of clinical application.