| 强迫症患者脑岛功能连接异常磁共振成像研究 |
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| 引用本文： | 李先瑞,张海三,杨勇峰,李坤,张玉娟,张猛,童文静,杜云红,寇延娜,吕路线,张红星.强迫症患者脑岛功能连接异常磁共振成像研究[J].中国心理卫生杂志,2020(4):316-321. |
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| 作者姓名： | 李先瑞 张海三 杨勇峰 李坤 张玉娟 张猛 童文静 杜云红 寇延娜 吕路线 张红星 |
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| 作者单位： | 新乡医学院心理学院;河南省精神病医院;新乡市多模态脑影像重点实验室;河南省生物精神病学重点实验室;河南省生理心理学实验室 |
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| 基金项目： | 国家自然科学基金河南省联合基金重点培育项目(U1704190);国家自然科学基金(81071091、81571315、31600927);河南省科技创新型杰出青年(174100510024);河南省高校科技创新团队支持计划(18IRTSTHN025);新乡医学院精神神经医学学科群开放课题(2016PN-KFKT-10、2016PN-KFKT-28);新乡医学院研究生创新课题(YJSCX201833Y);河南省教育厅科学技术研究重点项目(12A320018);河南省生物精神病学重点实验室开放课题(ZDSYS2014006、ZDSYS2015002)。 |
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| 摘 要： | 目的:探讨静息态下强迫症患者脑岛的功能连接特点。方法:纳入符合DSM-IV强迫症诊断标准的患者32例及性别、年龄、教育年限相匹配的正常对照37例,采用Y-BOCS量表评定强迫思维、强迫行为严重程度,应用3.0T磁共振成像系统进行静息态数据扫描。以双侧脑岛为感兴趣区(ROI)进行全脑功能连接(FC)分析,比较强迫症组与正常对照组之间的功能连接差异,并分析差异脑区功能连接强度与临床症状之间的关系。结果:与正常对照组相比,强迫症患者组的左侧脑岛与右侧缘上回、右侧顶下回、右侧顶上回的功能连接增强(FDR校正,P<0.01);右侧脑岛与右侧岛盖部额下回、左侧缘上回、右侧缘上回、右侧中央后回的功能连接增强(FDR校正,P<0.05);进一步分析发现,右侧脑岛与右侧中央后回的功能连接强度与强迫行为得分呈负相关(r=-0.35,P<0.05)。结论:强迫症患者脑岛的功能连接网络模式可能存在异常。
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| 关 键 词： | 强迫症 功能磁共振成像 脑岛 功能连接 |
A magnetic resonance imaging study of abnormal functional connectivity of insula in patients with obsessive-compulsive disorder |
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| LI Xianrui,ZHANG Haisan,YANG Yongfeng,LI Kun,ZHANG Yujuan,ZHANG Meng,TONG Wenjing,DU Yunhong,KOU Yanna,LYU Luxian,ZHANG Hongxing.A magnetic resonance imaging study of abnormal functional connectivity of insula in patients with obsessive-compulsive disorder[J].Chinese Mental Health Journal,2020(4):316-321. |
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| Authors: | LI Xianrui ZHANG Haisan YANG Yongfeng LI Kun ZHANG Yujuan ZHANG Meng TONG Wenjing DU Yunhong KOU Yanna LYU Luxian ZHANG Hongxing |
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| Institution: | (School of Psychology of Xinxiang Medical University,Xinxiang 453003,Henan Province,China;The Second Affiliated Hospital of Xinxiang Medical University,Xinxiang 453002,Henan Province,China;Xinxiang Key Laboratory of Multimodal Brain Imaging,Xinxiang453002,Henan Province,China;Henan Key Lab of Biological Psychiatry,International Joint Research Laboratory for Psychiatry and Neuroscience of Henan,Xinxiang 453002,Henan Province,China;Henan Physiological Psychology Laboratory,Xinxiang 453003,Henan Province,China) |
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| Abstract: | Objective:To explore the feature of functional connectivity of insula in patients with obsessivecompulsive disorder in resting state.Methods:Thirty-two patients who met the DSM-IVdiagnostic criteria and 37 normal controls matched by gender,age and education years were enrolled.The severity of compulsive-mind and compulsive-behavior were assessed by Y-BOCS scale.All participantswere scanned by the 3.OT functional magnetic resonance imaging.The whole brain functional connectivity was analyzed while regarding the bilateral insula as region of interest.The differences of functional connectivity between the OCD group and normal control group were compared,and the relationship between the clinical symptom and the functional connectivity of the different brain was analyzed.Results:The OCD group showed increased connections between the left insula and brain regions which included the right supramarginal gyrus,right inferior parietal cortex and right superior parietal cortex(FDR correct,P<0.01).The increased connections between the right insula and brain regions which included right inferior frontal operculum,left supramarginal gyrus,right supramarginal gyrus and right postcentral(FDR correct,P<0.01).Further analysis found that the compulsive-behavior was negatively correlated with the connections between right insula and right postcentral(r=-0.35,P<0.05).Conclusion:The results suggest that the abnormal connectivity of insula networks may occur in patients with obsessive-compulsive disorder. |
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| Keywords: | obsessive-compulsive disorder functional magnetic resonance imaging insula functional connectivity |
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