| 急腹症脓毒症患者外周血单核细胞的活化和复方清下汤的治疗作用 |
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| 引用本文： | 张盛林,陈海龙,殷 朔.急腹症脓毒症患者外周血单核细胞的活化和复方清下汤的治疗作用[J].大连医科大学学报,2010,32(3):294-298. |
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| 作者姓名： | 张盛林 陈海龙 殷 朔 |
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| 作者单位： | 大连医科大学附属第一医院,普外科,辽宁,大连,116011 |
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| 摘 要： | 目的]观察急腹症并发脓毒症患者外周血单核细胞肿瘤坏死因子的基因表达规律,探讨中药复方清下汤的治疗作用及可能机制.方法] 38例急腹症并发脓毒症患者随机分成两组,常规治疗组(常规组)和在常规治疗基础上给予中药复方清下汤治疗组(中药组).另设10例健康志愿者为对照组.患者分别于入院24 h内、3 d、7 d采取外周静脉血,测定血清TNF-α和血浆内毒素(endotoxin,ET)含量,RT-PCR法检测外周血单核细胞TNF-α mRNA表达水平.结果] 常规组与中药组各时间点血浆ET和血清TNF-α水平均高于对照组(P<0.05).同24 h相比,第7天时中药组血浆ET和血清TNF-α水平均明显下降(P<0.05),且低于常规组(P<0.05).24 h时常规组和中药组TNF-α mRNA表达水平同对照组相比明显升高(0.430±0.201),(0.502±0.233),(0.071±0.045),P<0.01],至第7 天时均明显降低(0.227±0.058),(0.150±0.065),P<0.01],中药组比常规组下降更明显(0.150±0.065),(0.227±0.058),P<0.05].入院24 h和7 d 时外周血单核细胞TNF-αmRNA的表达水平与血浆ET及血清TNF-α含量之间均呈显著正相关关系(r=0.473,P<0.05;r=0.782,P<0.01;r=0.575,P<0.05;r=0.787,P<0.01).结论] 急腹症并发脓毒症时,存在外周血单核细胞活化,TNF-α mRNA表达增强,TNF-α分泌增多.中药复方清下汤可有效降低血液中内毒素及TNF-α 水平,抑制外周血单核细胞的活化.
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| 关 键 词： | 急腹症 脓毒症 单核细胞 复方清下汤 肿瘤坏死因子 |
Peripheral blood monocyte activation in acute abdominal diseases with sepsis and its treatment with fufang qingxia decoction |
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| ZHANG Sheng-lin,CHEN Hai-long and YIN Suo.Peripheral blood monocyte activation in acute abdominal diseases with sepsis and its treatment with fufang qingxia decoction[J].Journal of Dalian Medical University,2010,32(3):294-298. |
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| Authors: | ZHANG Sheng-lin CHEN Hai-long and YIN Suo |
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| Institution: | Department of General Surgery, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China;Department of General Surgery, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China;Department of General Surgery, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China |
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| Abstract: | |
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| Keywords: | acute abdominal disease sepsis monocyte fufang qingxia decoction tumor necrosis factor-alpha |
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