联合应用降压药物防治高血压及其并发症的临床疗效观察

目的 探讨联合应用血管紧张素转换酶抑制剂和钙通道阻滞剂对防治高血压及其并发症产生的影响。方法 临床选取80例高血压患者，随机分为单独用药组和联合用药组，观察对血压、肝肾功能、血脂、血糖、肾小球滤过率等的影响。结果 联合用药组用药后降压效果显著，分别与单独用药组相对存在显著差异（P〈0．05）。而联合用药对肝肾功能、血脂、血糖等没有产生显著影响，但联合用药后血肌酐较用药前有显著改善（P〈0．05），而且与单独用药组相比，对GFR有显著升高的作用（P〈0．05）。结论 治疗高血压以血管紧张素转换酶抑制剂为首选；联合应用钙通道阻滞剂，治疗疗效十分理想，对靶器官具有较为理想的保护作用。

Efficacy of combination of multiple drugs in the management of hypertension

Objective To examine a proper treatment for hypertension in the patients with hypertension. Methods In this study,80 patients with hypertension were randomized into three arms of antihypertensive treatment: group A and group B treated with only one drug,group C treated with two drugs. At the same time, we tested the levels of GFR, renal function, liver function, glucose, etc. Results Eight weeks later, both SBP and DBP were decreased significantly in all of the patients(P<0. 05). The blood pressure was lower in the patients with two drugs than with only one drug. The renal functions of the patients with two drugs grown were better than those with only one drug( P < 0. 05). And the level of GFR was increased in the patients with two drugs. Conclusion Treatment of hypertension by combining ACEI and CCB is superior to the treatment alone, and the treatment can postpone the progression of the organ.