Pharmacogenomics and the Yin/Yang actions of ginseng: anti-tumor, angiomodulating and steroid-like activities of ginsenosides |
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| Authors: | Patrick Ying Kit Yue Nai Ki Mak Yuen Kit Cheng Kar Wah Leung Tzi Bun Ng David Tai Ping Fan Hin Wing Yeung Ricky Ngok Shun Wong |
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| Affiliation: | (1) Department of Biology, Faculty of Science, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China;(2) Department of Chemistry, Faculty of Science, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China;(3) Department of Biochemistry, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong SAR, China;(4) Angiogenesis & TCM Laboratory, Department of Pharmacology, University of Cambridge, Tennis Court Road, CB2 1PD, UK;(5) International Society for Chinese Medicine, University of Macau, A & C, 1st floor, Block 2, Av. Padre Tomas Pereira, Taipa, Macao SAR, China |
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| Abstract: | In Chinese medicine, ginseng (Panax ginseng C.A. Meyer) has long been used as a general tonic or an adaptogen to promote longevity and enhance bodily functions. It has also been claimed to be effective in combating stress, fatigue, oxidants, cancer and diabetes mellitus. Most of the pharmacological actions of ginseng are attributed to one type of its constituents, namely the ginsenosides. In this review, we focus on the recent advances in the study of ginsenosides on angiogenesis which is related to many pathological conditions including tumor progression and cardiovascular dysfunctions. |
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