Progressive Systemsklerose (diffuse Sklerodermie) und Goodpasture'sches Syndrom bei einer 47jährigen Frau |
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Authors: | V Dornetzhuber M Vagač P Krištúfek |
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Institution: | 1. Institut für Tuberkulose und Respirationskrankheiten, Bratislava, Podunajské Biskupice, ?SSR 2. Lehrstuhl für Tuberkulose und Respirationskrankheiten des Fortbildungsinstitutes für ?rzte und Pharmazeuten, Bratislava, Kramáre
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Abstract: | In a 47-year-old woman, suffering for 3 years of progressive systemic sclerosis (diffuse sclerodermia), Goodpasture's syndrome with a typical membranous proliferative glomerulonephritis and an acute hemosiderosis of the lungs was found in the late stage of the disease. Death was caused by uremia and cardio-respiratory insufficiency. In addition post-mortem examination revealed chronic intersititial nephrosis with pyramidal necrosis as well as eosinophilic infiltrates in the lung tissue and in the bronchial lumina. With the present knowledge, it is impossible to determine whether progressive systemic sclerosis and Goodpasture's syndrome are two independent nosological entities, or whether Goodpasture's syndrome is a part of the picture of the late stage of progressive systemic sclerosis. |
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