| 血脂代谢紊乱与外周血白细胞C5a受体表达的关系 |
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| 引用本文： | 张钦忠,刘永铭,薛芙珍,张小薇. 血脂代谢紊乱与外周血白细胞C5a受体表达的关系[J]. 兰州大学学报(医学版), 2008, 34(3) |
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| 作者姓名： | 张钦忠 刘永铭 薛芙珍 张小薇 |
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| 作者单位： | 甘肃省肿瘤医院,中西医结合科,甘肃,兰州,730050;兰州大学第一医院,老年病科,甘肃,兰州,730000 |
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| 摘 要： | 探讨血脂代谢紊乱与外周血白细胞C5a受体表达的关系.方法 高脂血症患者60人,同期正常对照30人,测定血清总胆固醇、甘油三酯、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、脂蛋白(a)、氧化低密度脂蛋(oxLDL)等脂代谢指标以及补体C3、C4,使用流式细胞仪检测外周血白细胞C5a受体,分析脂代谢异常以及补体C3、C45平与C5a受体表达的关系.结果 高脂血症组总胆固醇、甘油三脂、LDL-C、oxLDL、脂蛋白(a)、补体C3、C4等较对照组明显升高;高脂血症组CD88阳性淋巴细胞、单核细胞、粒细胞平均荧光强度有升高趋势(3.05±0.91比2.96±0.76、4.90±1.33比4.58±1.13、13.87±4.77比13.60±3.54),但差异无统计学意义(P>0.05);直线相关分析,CD88阳性单核细胞及粒细胞平均荧光强度与脂蛋白(a)正相关,CD88阳性单核细胞及粒细胞平均荧光强度与oxLDL亦呈正相关,与总胆固醇、甘油三脂、LDL-C、HDL-C、补体C3和C4不相关;偏相关分析及多元回归显示oxLDL是CD88阳性单核细胞及粒细胞平均荧光强度的独立预测因素.结论 oxLDL可能影响外周血白细胞C5a受体的表达.
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| 关 键 词： | 脂代谢异常 自细胞 C5a受体 动脉粥样硬化 |
Association of lipid disorders with the expression of C5a receptors on circulating white blood cells |
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| ZHANG Qin-zhong LIU Yong-ming XUE Fu-zhen ZHANG Xiao-wei. Association of lipid disorders with the expression of C5a receptors on circulating white blood cells[J]. Journal of Lanzhou University (Medical Sciences), 2008, 34(3) |
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| Authors: | ZHANG Qin-zhong LIU Yong-ming XUE Fu-zhen ZHANG Xiao-wei |
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| Affiliation: | ZHANG Qin-zhong~1 LIU Yong-ming~2 XUE Fu-zhen~2 ZHANG Xiao-wei~2 (1.Department of Integrated Traditional , Western Medicine,Tumor Hospital of Gansu Province,Lanzhou 730050,China,2.Department of Gerontology,the First Hospital of Lanzhou University,Lanzhou 730000,China) |
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| Abstract: | Objective To investigate the relationship between lipid disorders and the expression of CSa receptors on circulating white blood cells.Methods We selected 60 consecutive patients with hyperlipidemia and 30 healthy people during the same period as controls.The expression of C5a receptors on white blood cells were tested by flow cytometry in all subjects,and it's association with total cholesterol,triglyceride,low density lipoprotein eholesterol(LDL-C),high density lipoprotein eholesterol(HDL-C),lipoprotein(a... |
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| Keywords: | dyslipidemia white blood cells C5a receptor(CD88) atherosclerosis |
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