Antihypertensive effects of L-tryptophan are not mediated by brain serotonin |
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| Authors: | W A Wolf D M Kuhn |
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| Affiliation: | Section on Biochemical Pharmacology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20205, U.S.A. |
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| Abstract: | L-Tryptophan produces a significant antihypertensive effect in spontaneously hypertensive rats while D-tryptophan does not change blood pressure. Both isomers of tryptophan significantly increase brain serotonin to the same extent at a time when the antihypertensive effect of L-tryptophan is maximal. Thus, the antihypertensive effects of L-tryptophan do not appear to be mediated by brain serotonin. |
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| Keywords: | serotonin blood pressure spontaneously hypertensive rats |
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