| 双嘧达莫对腺苷抗心律失常作用的影响 |
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| 引用本文： | 张俊,范常龙,栾彦,冯铁明,张婉,陈燕,杨宝峰,董德利. 双嘧达莫对腺苷抗心律失常作用的影响[J]. 中国药理学通报, 2007, 23(8): 1080-1083 |
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| 作者姓名： | 张俊 范常龙 栾彦 冯铁明 张婉 陈燕 杨宝峰 董德利 |
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| 作者单位： | 哈尔滨医科大学药学院药理学教研室,黑龙江省生物医药重点实验室,黑龙江,哈尔滨,150086 |
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| 基金项目： | 黑龙江省杰出青年科学基金;教育部跨世纪优秀人才培养计划 |
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| 摘 要： | 目的探讨腺苷在整体水平下的抗心律失常作用以及双嘧达莫对腺苷抗心律失常作用的增效作用。方法经大鼠尾静脉快速推注不同药物,应用BL-420E生物机能实验系统记录和分析单独应用腺苷以及双嘧达莫合用腺苷对正常大鼠、肾上腺素诱导心律失常大鼠、氯化钡诱导心律失常大鼠心电变化的影响。结果腺苷能够明显减慢健康大鼠的心律,延长R-R间期,并且这种作用具有剂量依赖性;腺苷此作用还可被双嘧达莫增强;腺苷在作用时间内还能够快速终止肾上腺素和氯化钡所致的大鼠室性心律失常,合用双嘧达莫能够明显延长腺苷的抗心律失常作用时间。结论腺苷能够有效对抗肾上腺素和氯化钡所致室性心律失常,合用双嘧达莫可增强腺苷的抗心律失常作用。
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| 关 键 词： | 腺苷 双嘧达莫 肾上腺素 氯化钡 心律失常 |
| 文章编号： | 1001-1978(2007)08-1080-04 |
| 修稿时间： | 2007-02-28 |
Effects of dipyridamole on the antiarrhythmic action of adenosine in rats |
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| ZHANG Jun,FAN Chang-long,LUAN Yan,FENG Tie-ming,ZHANG Wan,CHEN Yan,YANG Bao-feng,DONG De-li. Effects of dipyridamole on the antiarrhythmic action of adenosine in rats[J]. Chinese Pharmacological Bulletin, 2007, 23(8): 1080-1083 |
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| Authors: | ZHANG Jun FAN Chang-long LUAN Yan FENG Tie-ming ZHANG Wan CHEN Yan YANG Bao-feng DONG De-li |
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| Abstract: | Aim To approach the antiarrhythmic effects of adenosine and the synergistic antiarrhythmic effects of combination of adenosine and dipyridamole.Methods Different drugs were injected into rats through vena caudalis.The electrocardiogram(ECG)was recorded and analyzed by using BL-420E system.Results Adenosine significantly prolonged the R-R interval in a dose-dependent manner and the effects were enhanced by combination with dipyridamole.Adenosine terminated ventricular arrhythmia induced by adrenalin and BaCl2 in rats and the antiarrhythmic effects were prolonged by combination with dipyridamole.Conclusion Adenosine antagonized the ventricular arrhythmias induced by adrenalin and BaCl2 in rats and the antagonism was enhanced by combination with dipyridamole. |
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| Keywords: | adenosine dipyridamole adrenalin BaCl2 arrhythmias |
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