Characterization of Papillary Thyroid Microcarcinomas Using Sonographic Features in Malignant Papillary Thyroid Cancer: A Retrospective Analysis |
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| Authors: | Wei-jun Gu Hui-xian Yan Yu-kun Luo Fu-lin Wang Guo-qing Yang Qing-hua Guo Nian Jin Li Zang Kang Chen Jin Du Xian-ling Wang Li-juan Yang Jian-ming Ba Jing-tao Dou Yi-ming Mu Chang-yu Pan Zhao-hui Lv |
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| Affiliation: | From the Department of Endocrinology (WG, HY, GY, QG, NJ, LZ, KC, JD, XW, LY, JB, JD, YM, CP, ZL), PLA General Hospital; Beijing Haidian Hospital (HY); Department of Ultrasonography (YL); and Department of Pathology (FW), PLA General Hospital, Beijing, China. |
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| Abstract: | The diagnosis of malignant thyroid nodules is still a clinical challenge. This study aimed to determine the ultrasonographic characteristics of papillary thyroid carcinoma.The ultrasonographic and pathological data of 2453 thyroid nodules in a cohort of 1895 Chinese patients who underwent thyroidectomy from January 2010 to December 2012 were retrospectively reviewed.Anteroposterior and transversal (AP/TR) diameters ≥1, solid structure, infiltrative margins, hypoechoic appearance, and microcalcifications were more common in malignant nodules than in benign nodules (P < 0.01). These ultrasonographic features were independent risk factors of malignancy (P < 0.01) as determined by logistic regression analysis. Based on multivariate analysis, these characteristics were also present in large nodules (diameter >10 mm). However, in small nodules (diameter ≤10 mm), only AP/TR ≥1 and infiltrative margins were independent risk factors of malignancy (P < 0.01).Ultrasonography is of high diagnostic value for malignant thyroid nodules and may help to improve the differential diagnosis. Small and large nodules have distinct ultrasonographic features. |
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