Renal Vein Thrombosis in a Newborn With Abnormal Factor VIII Level: Clinical Case Report |
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Authors: | Agnieszka Szafranska Agata Pajak Katarzyna Kilis-Pstrusinska Barbara Królak-Olejnik |
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Institution: | From the Department of Neonatology (AS, AP, BKO); and Department of Pediatric Nephrology, Wroclaw Medical University, Wroclaw, Poland (KK). |
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Abstract: | Renal vein thrombosis (RVT) in neonates is a rare condition of low mortality but significant morbidity due to renal impairment.We report the case of a male term newborn with left RVT and elevated serum factor VIII (FVIII).The main symptoms of the patient and the important clinical findings: prompt diagnosis of RVT was possible because the classic clinical presentation of macroscopic hematuria, thrombocytopenia, and palpable flank mass were present in this newborn infant.The main diagnoses: finally, the reason of RVT was established when the infant was 3 months of age: the increased level of FVIII was confirmed. We discuss the diagnosis, therapy, and outcome of the patient and compare with the literature.Therapeutics interventions: however, despite anticoagulant therapy the left kidney developed areas of scarring and then atrophy.Conclusions and outcomes: Prothrombotic defects should be considered in all patients with perinatal RVT. Elevated factor VIII as a reason of RVT in neonatal period is particularly rare. Given a poor renal outcome in children associated with elevated levels of factor VIII, consideration could be given to more aggressive antithrombotic therapy in such cases. |
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