The skeletal dysplasias |
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| Affiliation: | 1. Departments of Orthopaedic Surgery, Human Genetics, and Obstetrics and Gynecology, David Geffen School of Medicine at UCLA;;2. Medical Genetics Institute at Cedar-Sinai Medical Center;;3. Departments of Pediatrics, Internal Medicine and Human Genetics, David Geffen School of Medicine at UCLA, Los Angeles, CA. |
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| Abstract: | The skeletal dysplasias (osteochondrodysplasias) are a heterogeneous group of more than 350 disorders frequently associated with orthopedic complications and varying degrees of dwarfism or short stature. These disorders are diagnosed based on radiographic, clinical, and molecular criteria. The molecular mechanisms have been elucidated in many of these disorders providing for improved clinical diagnosis and reproductive choices for affected individuals and their families. An increasing variety of medical and surgical treatment options can be offered to affected individuals to try to improve their quality of life and lifespan. |
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