我院2012年276例药品不良反应报告分析

目的：分析我院2012年276例药品不良反应的发生特点,为临床合理用药提供参考。方法：利用Excel 2003软件对ADR病例的年龄、性别,引发ADR的药品类别、给药途径、药物剂型,ADR累及器官或系统及临床表现,报告人员职业等进行统计分析。结果：276例ADR报告中,男125例（45.3%）,女151例（54.7%）;以静脉滴注方式给药的ADR比例较高,为193例（69.93%）;以注射剂出现的ADR为多,167例（60.51%）;所涉及的药品中抗菌药引起的ADR比例较高,65例（23.55%）;引起ADR的药品前10位中有9个为抗菌药;严重的ADR共3例（1.09%）;ADR临床表现以皮肤及其附件损害为主,55例（18.71%）,其次为全身性损害,35例（11.90%）;填报ADR报告的以药师为主（61.23%）,其次为护士（32.61%）,医生较少（6.16%）。结论：应加强ADR的监测并重视在ADR报告中发现的用药问题,并及时向临床反馈,促进临床合理用药。

Analysis of 276 Adverse Drug Reaction Reports of Our Hospital in 2012

Objective：To analyze the characteristics of the adverse drug reaction in our hospital, and provide reference for rational drug use in clinic. Methods： The data were extracted and analyzed by Excel 2003 in respect of age, gender, route of administration, pharmaceutical dosage forms, organs or systems involved in ADRs, ect. Results ： Among the 276 ADR cases, 125 cases （45.3%） were male and 151 cases （54.7%） were female. The occurrence of ADRs caused by intravenous administration were the highest （ 193 eases, 69.93% ）, meanwhile the most dosage involved was injection （167 cases,60.51% ） ; and most ADRs were caused by antibacterial drugs （65 cases, 23.55% ） ; among the top 10 ADR-inducing drugs there were 9 antibacterial drugs ; 3 serious ADRs （1.09%） were found; The skin and its appendages damages （55 cases, 18.71% ） were the most common clinical manifestations of ADRs, followed by systemic damages （35 cases, 11.90% ） ; pharmacists reported 169 ADR reports （61.23%）, followed by nurses （32.61%）, and the doctors reported the less （6.16%）. Conclusion： ADR monitoring should be strengthened , much consideration should be taken on the problems found in ADR reports, and immediate feedbacks should be given to the clinicians to promote rational druuse.