Epidemiology of multiple system atrophy |
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| Authors: | N. Vanacore V. Bonifati G. Fabbrini C. Colosimo G. De Michele R. Marconi D. Nicholl N. Locuratolo G. Talarico S. Romano F. Stocchi U. Bonuccelli M. De Mari P. Vieregge G. Meco |
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| Affiliation: | (1) Department of Neurological Sciences, La Sapienza University, Viale dell'Università 30, I-00185 Rome, Italy, IT;(2) Department of Neurological Sciences, Federico II University, Naples, Italy, IT;(3) Neurology Service, Misericordia Hospital, Grosseto, Italy, IT;(4) Department of Neurological Sciences, University of Birmingham, Birmingham, UK, GB;(5) Institute of Neurology, University of Pisa, Pisa, Italy, IT;(6) Institute of Neurology, University of Bari, Bari, Italy, IT;(7) Klinik fur Neurologie, Klinikum Lippe-Lemgo, Lemgo, Germany, DE |
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| Abstract: | Multiple system atrophy (MSA) is a form of atypical parkinsonism with unknown etiology. The epidemiological studies conducted up to now on this disease are scarce. The incidence rate is about 0.6 cases per 100 000 persons per year. The prevalence rates show 4–5 cases per 100 000 persons. In Italy, about 4900 prevalent cases have been estimated. The mean onset age is about 54 years; the median survival is 7–9 years. Only one case-control study has been performed on this disease. This study showed an increased risk MSA associated with occupational exposure to organic solvents, plastic monomers and additives, pesticides and metals. Smoking habits seem to be less frequent in MSA cases (as in Parkinson's disease cases) than in healthy controls. Quinn's clinical criteria and those of the Consensus Conference promoted by the American Academy of Neurology are in fair agreement. We have performed a case-control study on 73 MSA cases, 146 hospital controls and 73 population controls. |
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