度洛西汀和文拉法新治疗老年期抑郁障碍的对照研究

目的：对照研究度洛西汀和文拉法新治疗老年期抑郁障碍的疗效、安全性。方法110例老年抑郁症患者随机分为研究组和对照组，各55例，研究组给予度洛西汀口服，对照组给予文拉法新口服，在治疗前、治疗1、2、4、8周末采用24-汉密尔顿抑郁量表（HAMD）进行疗效评定， TESS量表进行不良反应评定。结果在治疗1周末研究组和对照组HAMD评分均有下降，差异无统计学意义（P〉0.05），在治疗2、4、8周末HAMD评分差异无统计学意义（P〉0.05）。TESS量表总体评价差异无统计学意义（P〉0.05），文拉法新引起血压升高较多，度洛西汀片引起恶心、呕吐较多。结论度洛西汀和文拉法新起效时间、临床疗效、总体副反应相当，度洛西汀质优价廉，值得推广。

Control study of duloxetine and venlafaxine in the treatment of depressive disorder in the elderly

Objective To make a control study of the curative effect and safety of duloxetine and venlafaxine in the treatment of depressive disorder in the elderly. Methods A total of 110 elder patients with depression were randomly divided into two groups, and 55 cases in each group. The research group was given duloxetine through oral administration, and the control group was given venlafaxine. Efficacies were assessed by 24-Hamilton Depress Scale（HAMD）, and safety were assessed by Treatment Emergent Symptom Scale（TESS） at baseline and the end of 1st,2nd,4th, and 8th week. Results In treatment group and control group at the end of 1 st week HAMD scores were all decreased, and there was no statistical significance （P〉0.05）. The HAMD scores at the end of the 2nd, 4th, and 8th weeks were not statistically significant （P〉0.05）. TESS scale had no statistical significance in the overall valuation （P〉0.05）. Venlafaxine causes more cases of high blood pressure, and duloxetine causes more cases of nausea and vomiting. Conclusion Duloxetine and venlafaxine effect similarly in the working time , curative effect and safety, but duloxetine is cheaper and worth promoting.