Unit of Sleep Disorders, University Hospital Marqués de Valdecilla, School of Medicine, University of Cantabria, Herrera Oria s/n, 39011 Santander, Spain.
Abstract:
This report describes the case of a 4-year-old boy diagnosed with Smith-Magenis syndrome in whom treatment with a beta(1)-adrenergic antagonist in the morning (to suppress the diurnal melatonin secretion) and melatonin in the evening (to generate a nocturnal peak of melatonin) improved his sleep quality, evaluated by polysomnographic studies.