| mPEG表面修饰的PLGA嵌段共聚物的血液相容性评价 |
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| 引用本文： | 聂宇,段友容,张志荣.mPEG表面修饰的PLGA嵌段共聚物的血液相容性评价[J].生物医学工程学杂志,2007,24(2):336-339. |
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| 作者姓名： | 聂宇 段友容 张志荣 |
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| 作者单位： | 1. 四川大学,华西药学院,成都,610041
2. 东华大学,材料科学与工程学院,上海,200051 |
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| 基金项目： | 国家高技术研究发展计划(863计划) |
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| 摘 要： | 本实验室设计合成了三种不同LA／GA比例的mPEG修饰PLGA（PELGA，含15％mPEG），为了评价它们的血液相容性，我们以硅化玻璃试管为阴性对照，未硅化的试管为阳性对照，参照国际标准（ISO10993）和《中华人民共和国国家标准GB／T16886医疗器械生物学评价》方法进行了体外评价实验。试验包括溶血率实验，血小板黏附实验，动态凝血时间实验，凝血时间实验，血浆复钙时间实验和凝血酶原时间实验等综合评价指标。结果表明，合成材料具有优良的血液相容性，材料制成的纳米粒有望应用于静脉注射。
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| 关 键 词： | 聚乙交酯丙交酯 聚乙烯醇 嵌段共聚物 血液相容性 静脉注射 |
| 修稿时间： | 2004-12-022005-03-31 |
Evaluation of Blood Compatibility of Surface Modification Treated Poly(D,L-lactic and glycolic acid) with mPEG Block Copolymer |
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| Nie Yu,Duan Yourong,Zhang Zhirong.Evaluation of Blood Compatibility of Surface Modification Treated Poly(D,L-lactic and glycolic acid) with mPEG Block Copolymer[J].Journal of Biomedical Engineering,2007,24(2):336-339. |
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| Authors: | Nie Yu Duan Yourong Zhang Zhirong |
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| Institution: | 1.West China Pharmacy College of Sichun University, Chengdu Sichuan 610041,China; 2.School of Materials Science and Engineering, Donghua University, Shanghai 200051 ,China |
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| Abstract: | To identify the advantages of modification treated ploy (D. L -lactic and glycolic acid) with poly (ethylene glycol) (PLGA/mPEG.PELGA) block copolymer, blood compatibility was evaluated in vitro. Three different proportional block copolymers (LA/GA80: 20, 70:30, 50:50) with 15% mPEG were synthesized. According to the international standard organization (ISO10993) and National Standards of P. R. China GB/T 16886, siliconized glass tube was used as a negative control sample, while non-siliconized glass tube as a positive one. Blood compatibility of PELGA was evaluated by hemolytic ratio analysis, platelet adhesion investigation, dynamic clotting time, plasma recalcification time (PRT) measurements, plasma prothrombin time (PT) and clotting time (CT) test. The results revealed that blood compatibility of the synthesized materials was good. Nanoparticles made by this kind of materials might be promising for intravenous use. |
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| Keywords: | Ploy (D L-lactic and glycolic acid)(PLGA) Poly (ethylene glycol)(PEG) Block copolymer Blood compatibility Intravenous injection |
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