二噁英暴露与2型糖尿病发病关系的流行病学研究进展

二噁英类化合物既是环境内分泌干扰物,又是一种持久性有机污染物,由于其具有难以降解、可生物累积、可远距离传输等特性,因此无论是接触二噁英作业的职业人群和居住在二噁英排放源周边的居民,还是远离二噁英暴露源的一般人群,都会不同程度的暴露于二噁英的污染。近年来的研究发现,除遗传、生活方式等传统因素之外,环境因素特别是二噁英类化合物身体负荷的增加也增加了患糖尿病的风险,但作用机制尚不明确。笔者将对二噁英影响2型糖尿病发病的流行病学研究进展作简要介绍。

Epidemiological research progress on relationship between dioxins exposure and type 2 diabetes

Dioxins are environmental endocrine disruptors and persistent organic pollutants. Whether the professional population and the residents living around the dioxin emission sources, or the general population staying away from the exposure source of dioxin couldn＇t avoid exposing to different levels of dioxin contamination, for its difficult degradable, bioaccumulation, long-distance transmission and other features. Recent studies have found that in addition to traditional risk factors such as heredity and life style, the environmental factors, in particular to body load increasing of dioxin-like compounds also increases the risk of diabetes, however, the mechanism is not clear. This paper will make a brief introduction of epidemiological research progress on relationship between type 2 diabetes and dioxin exposure.