南京地区育龄女性TORCH感染状况调查

目的调查在南京大学医学院附属鼓楼医院进行孕前筛查和产前普查的育龄女性的TORCH感染情况,分析不同季节、不同年龄段人群TORCH感染的特征,为该地区育龄女性的预防保健提供参考依据。方法采用酶联免疫吸附试验对3 340例孕前及孕期妇女进行血清中TORCH特异性抗体IgM、IgG检测,根据季节、年龄分组比较TORCH不同病原体感染率的差异。结果 3 340例受检者中总IgM阳性率为2.6%,巨细胞病毒（CMV）的IgM阳性（近期感染）率和IgG阳性（既往感染）率分别为1.05%和65.14%;弓形虫（TOX）、风疹病毒（RV）和CMV IgM的检出率均在夏季最高,夏季TOX和RV IgM阳性率分别为1.38%和1.30%,显著高于其他3个季节（P〈0.01）;20-25岁年龄组TOX IgM检出率（1.08%）显著高于26-30岁组（0.36%）（P〈0.05）;CMV IgM的阳性率在20-25岁组最高,为1.49%,与31-45岁组（0.47%）差异有统计学意义（P〈0.05）。结论育龄女性TORCH感染以CMV最多见,相关病原体感染具有季节性和年龄差异,有必要有针对性地加强预防保健,并积极做好TORCH特异性抗体的检测和监测。

Investigation of TORCH infection among reproductive age women in Nanjing Area

[Objective]To investigate the TORCH infection features in different season and age among reproductive women who received pre-pregnancy screening and prenatal screening in Nanjing Drum Tower Hospital,and provide reference for the health care in this area.[Methods]TORCH specific IgM and IgG detection on 3 340 cases of serum from reproductive women were conducted.The difference of infection rate of different TORCH pathogens was compared between groups according to season and age.[Results]The total positive rate of TORCH IgM was 2.6% in all 3 340 cases,while positive rates of CMV IgM（ recent infection）and IgG（ past infection） were 1. 05% and 65. 14%,respectively（ P〈0. 01）. As to season,the positive rate of TOX IgM,RV IgM and CMV IgM was highest in summer,the positive of TOX IgM（ 1. 38%） and RV IgM（ 1. 30%） in summer were significant higher than in other 3 seasons（ P〈0. 05）. The positive rate of TOX IgM in 20-25 years age group（ 1. 08%） was significant higher than 26-30 years group（ 0. 36%）（ P〈0. 05）. The positive rate of CMV IgM in 20-25 years age group was 1. 49%,with significant difference compared with 31-45 years age group（ 0. 47%）（ P〈0. 05）. [Conclusion]CMV infection is the most common TORCH infection among reproductive women and the infection of certain TORCH pathogens had seasonal and age-related pattern. It is necessary to strengthen preventive health care,and to actively do well in routine TORCH detection and monitoring of specific antibodies,.