Contribution of 5-HT1A serotonin receptors of the brain to the regulation of hereditary catalepsy |
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| Authors: | N K Popova A V Kulikov D F Avgustinovich G B Vishnivetskaya V G Kolpakov |
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| Institution: | (1) Department of Behavioral Phenogenetics, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk |
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| Abstract: | Selective agonists 5-HT1A of serotonin receptors (8-OH-DPAT and flezinoxan) had an inhibitory effect on the manifestation of hereditary catalepsy in
mice and rats. No differences were revealed in specific binding of3H-8-OH-DPAT to 5-HT1A receptors in the striatum of either cataleptic or noncataleptic mice and rats. Nonetheless, an increase of the density of
these receptors was observed in the frontal cortex of CBA mice predisposed to catalepsy in comparison with mice of the noncataleptic
C57Bl strain. The data indicate a contribution of 5-HT1A receptors to the regulation of hereditary catalepsy.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
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12, pp. 633–635, December, 1994
Presented by V. P. Kaznacheev, Member of the Russian Academy of Medical Sciences |
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| Keywords: | 5-HT 1A receptors hereditary catalepsy flezinoxan |
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