调强放疗对非小细胞肺癌患者生存情况、血清CA125水平及不良反应的影响

目的探讨调强放疗对非小细胞肺癌患者生存情况、血清CA125水平及不良反应的影响。方法选取非小细胞肺癌患者74例,将患者随机分为对照组和观察组,每组37例。对照组采用三维适形放疗(3D-CRT),观察组采用调强放疗(IMRT)。观察比较两组患者的近期治疗效果等情况。结果观察组和对照组患者总有效率分别为75.68%、72.97%,差异无统计学意义(P>0.05)。观察组和对照组患者的1年生存率为75.68%、67.56%,差异有统计学意义(P<0.05)。观察组患者的血清CA125水平为(76.32±8.25),低于对照组(101.38±15.24),差异有统计学意义(P<0.05)。观察组不良反应发生包括白细胞减少、血小板减少、消化道反应、放射性肺炎、放射性食管炎,明显较对照组低,差异有统计学意义(P<0.05)。观察组的CI值低于对照组,HI值高于对照组,差异有统计学意义(P<0.05)。结论调强放疗和三维适形放疗,对非小细胞肺癌患者的治疗疗效相近,调强放疗能够有效降低患者的血清CA125水平,减少不良反应的发生,并且靶区剂量分布更加合理。

Effects of Intensity-modulated Radiation Therapy on Survival Situation,Serum CA125 Levels and Adverse Reactions in Patients with Non-small Cell Lung Cancer

Objective To explore the effects of intensity-modulated radiation therapy on survival situation,serum CA125 levels and adverse reactions in patients with non-small cell lung cancer.Methods 74 patients with NSCLC were selected and randomly divided into the control group and the observation group,with 37 patients in each group.The control group was treated with three-dimensional conformal radiotherapy(3d-crt),the observation group was treated with intensity-modulated radiation therapy(IMRT).the short-term therapeutic effect,annual survival,serum CA125 level,adverse reactions and target dose distribution of the 2 groups were observed and compared.Results The total effective rate of the observation group and the control group was 75.68%and 72.97%,respectively,with no statistically significant difference(P>0.05).The 1-year survival rate of the observation group and the control group was 75.68%and 67.56%(P<0.05).The serum CA125 level of the observation group(76.32±8.25)was lower than that of the control group(101.38±15.24)(P<0.05).The adverse reactions in the observation group included leukopenia,thrombocytopenia,gastrointestinal reactions,radioactive pneumonia and radioactive esophagitis,which were significantly lower than those of the control group(P<0.05).The CI value of the observation group was lower than that of the control group,and the HI value of which was higher than that of the control group(P<0.05).Conclusion Intensity-modulated radiation therapy and three-dimensional conformal radiotherapy have similar therapeutic effects in patients with non-small cell lung cancer,but IMRT can effectively reduce the serum CA125 level of patients,reduce the occurrence of adverse reactions,and the dose distribution in the target area is more reasonable.