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Circulating cell-free DNA in health and disease — the relationship to health behaviours,ageing phenotypes and metabolomics |
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| Authors: | Kananen Laura Hurme Mikko Bürkle Alexander Moreno-Villanueva Maria Bernhardt Jürgen Debacq-Chainiaux Florence Grubeck-Loebenstein Beatrix Malavolta Marco Basso Andrea Piacenza Francesco Collino Sebastiano Gonos Efstathios S Sikora Ewa Gradinaru Daniela Jansen Eugene H J M Dollé Martijn E T Salmon Michel Stuetz Wolfgang Weber Daniela Grune Tilman Breusing Nicolle Simm Andreas Capri Miriam Franceschi Claudio Slagboom Eline Talbot Duncan Libert Claude Raitanen Jani Koskinen Seppo Härkänen Tommi Stenholm Sari Ala-Korpela Mika Lehtimäki Terho Raitakari Olli T Ukkola Olavi Kähönen Mika Jylhä Marja Jylhävä Juulia |
| Institution: | 1.Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden ;2.Faculty of Social Sciences (Health Sciences), and Gerontology Research Center, Tampere University, Tampere, Finland ;3.Faculty of Medicine and Health Technology, and Gerontology Research Center, Tampere University, Tampere, Finland ;4.Molecular Toxicology Group, University of Konstanz, Konstanz, Germany ;5.BioTeSys GmbH, 73728, Esslingen, Germany ;6.URBC-Narilis, University of Namur, Rue de Bruxelles, 61, B-5000, Namur, Belgium ;7.Research Institute for Biomedical Aging Research, University of Innsbruck, Rennweg, 10, 6020, Innsbruck, Austria ;8.Advanced Technology Center for Aging Research, Scientific Technological Area, IRCCS INRCA, Ancona, Italy ;9.Nestlé Research, Nestlé Institute of Health Sciences, EPFL Innovation Park, 1015, Lausanne, Switzerland ;10.Institute of Biology, Medicinal Chemistry and Biotechnology, National Hellenic Research Foundation, Athens, Greece ;11.Laboratory of the Molecular Bases of Ageing, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur street, 02-093, Warsaw, Poland ;12.Department of Biochemistry, Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 020956, Bucharest, Romania ;13.National Institute for Public Health and the Environment (RIVM), Centre for Health Protection, P.O. Box 1, 3720 BA, Bilthoven, The Netherlands ;14.Straticell, Science Park Crealys, Rue Jean Sonet 10, 5032, Les Isnes, Belgium ;15.Institute of Nutritional Sciences (140), University of Hohenheim, 70593, Stuttgart, Germany ;16.Department of Molecular Toxicology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, Germany ;17.Department of Physiological Chemistry, Faculty of Chemistry, University of Vienna, 1090, Vienna, Austria ;18.Institute of Nutritional Medicine (180), University of Hohenheim, 70593, Stuttgart, Germany ;19.Department of Cardiothoracic Surgery, University Hospital Halle, Ernst-Grube Str. 40, 06120, Halle (Saale), Germany ;20.DIMES- Department of Experimental, Diagnostic and Specialty Medicine, Interdepartmental Center “Alma Mater Research Institute On Global Challenges and Climate Change (Alma Climate)”, Alma Mater Studiorum, University of Bologna, 40126, Bologna, Italy ;21.Section of Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands ;22.Unilever Science and Technology, Beauty and Personal Care, Sharnbrook, UK ;23.Center for Inflammation Research, VIB, Ghent, Belgium ;24.Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium ;25.National Institute for Health and Welfare, Helsinki, Finland ;26.Department of Public Health, University of Turku and Turku University Hospital, Turku, Finland ;27.Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland ;28.Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland ;29.Center for Life Course Health Research, University of Oulu, Oulu, Finland ;30.NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland ;31.Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland ;32.Finnish Cardiovascular Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland ;33.Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland ;34.Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland ;35.Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland ;36.Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital, University of Oulu, Oulu, Finland ;37.Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland ; |
| Abstract: | GeroScience - Circulating cell-free DNA (cf-DNA) has emerged as a promising biomarker of ageing, tissue damage and cellular stress. However, less is known about health behaviours, ageing phenotypes... |
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