Variation of Perioperative Blood cTnT Levels in Patients Undergoing Cardiopulmonary Bypass and Its Clinical Implication

The measures we used in the past for detectingmyocardial cell damage are not sufficiently specificand sensitive for accurate diagnosis. Cardiac troponinT ( c Tn T) is a cardiac contractile apparatus proteinand is released into the circulation if myocardial is-chemia results in either reversible or irreversible cellinjury. The purpose of this study was to investigatethe clinicalvalueofc Tn T asa markerin assessing thedestruction of myocardial cell in patients undergoingopen heartsurgery.1　PA…

Variation of perioperative blood cTnT levels in patients undergoing cardiopulmonary bypass and its clinical implication

The clinical value of cardiac Troponin T (cTnT) as a marker in assessing myocardial cell damage in the patients undergoing open heart surgery was studied. Serum cTnT and CK MB levels were measured in serial blood samples from 20 patients undergoing open heart surgery before operation, at aorta clamping, aorta opening, the end of CPB and the operation, and subsequently one h, one day, 3 days and one week after operation respectively. Ten patients receiving thoracic surgery were also subjected to the measurement of cTnT and CK MB before and 24 h after operation. The results showed that peak concentrations were reached earlier in cTnT than in CK MB, and the circulation cTnT remained high when CK MB had already decreased to normal. In 10 patients receiving thoracic surgery, cTnT level was normal and CK MB was increased in 4 patients after surgery. It was concluded that the sensitivity and specificity of cTnT was more than those of CK MB and cTnT could be used as a routine indicator for myocardiac protection.