肝静脉流速曲线波型与肝纤维化关系的实验研究

目的 探讨肝静脉流速曲线波型与肝纤维化间的关系。方法 20只健康家兔以浓度为1．2g／L的硫代乙酰胺溶液作为唯一饮用水的方法建立肝纤维化动物模型，分别在建立模型前、建立模型中第8周、第12周、第16周时对所有实验动物进行肝静脉流速曲线波型检测，并与肝组织穿刺活检结果相比较。结果 随着建立模型时间的延长，肝静脉流速曲线波型发生异常改变的实验兔数目增多，第16周时与正常时比较，差异有非常显著性意义。结论 肝静脉流速曲线波型的改变在一定的程度上反映了肝实质病变情况。

Experimental study on the relation between the Doppler waveform of the hepatic venous flow and the hepatic fibrosis

Objective To access the relation between the Doppler waveform of the hepatic venous flow and the hepatic fibrosis.Methods To construct fibrosis models,20 experimental rabbits were fed with thioacetamide as the only drinking water at the concentration of 1.2 g/L,then the Doppler waveforms of the hepatic vein were detected at the time before constructing the fibrosis model,then later the 8th week,12th week and 16th week during constructing the fibrosis models,the results were compared with the hepatic biopsy ones.Results With the process of constructing the fibrosis models,the experimental rabbits had more abnormal Doppler waveforms of the hepatic venous flow.Conclusions The changes of the Doppler waveforms of the hepatic venous flow reflect the change of hepatic parenchyma.