| 防治急性胰腺炎并发肝脏损害的实验研究 |
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| 引用本文： | 刘金彪,姚榛祥,刘胜春.防治急性胰腺炎并发肝脏损害的实验研究[J].中国普外基础与临床杂志,2004,11(6):498-501. |
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| 作者姓名： | 刘金彪 姚榛祥 刘胜春 |
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| 作者单位： | 1. 河南科技大学第一附属医院普外科,洛阳,471003
2. 重庆医科大学附属第一医院普外科,重庆,400016 |
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| 摘 要： | 目的 探讨急性胰腺炎(AP)时大鼠肝脏损害及中药七叶皂苷钠对该损害的影响。方法 将大鼠分成3组．对照组、AP组和七叶皂苷钠治疗组(简称治疗组)。通过对AP大鼠静脉注射七叶皂苷钠,测定各组肝组织内能荷及ATP的含量、血清乳酸脱氢酶、谷丙转氨酶和血清蛋白含量等各项指标．并观察胰腺和肝组织的病理变化。结果 治疗组较AP组肝组织内细胞能荷及ATP的含量高，肝功能损害轻。结论 AP时常伴肝脏功能受损，应用七叶皂苷钠静脉注射，可以减轻AP大鼠肝脏损害。
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| 关 键 词： | 急性胰腺炎 并发症 肝脏损害 实验 预防 治疗 七叶皂苷钠 中药 |
| 文章编号： | 1007-9424(2004)06-0498-04 |
| 修稿时间： | 2003年10月27 |
Protective Effects of Aescin on Rat Liver in Acute Pancreatitis |
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| LIU Jin-biao ,YAO Zhen-xiang,LIU Sheng-Chun.Protective Effects of Aescin on Rat Liver in Acute Pancreatitis[J].Chinese Journal of Bases and Clinics In General Surgery,2004,11(6):498-501. |
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| Authors: | LIU Jin-biao YAO Zhen-xiang LIU Sheng-Chun |
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| Institution: | LIU Jin-biao *,YAO Zhen-xiang,LIU Sheng-Chun. *Department of General Surgery,The First Affiliated Hospital,Henan Science and Technology University,Luoyang 471003,China |
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| Abstract: | Objective To study the liver injury and effects of aescin on liver in rats with acute pancreatitis. Methods The rats were divided into 3 groups (control group, AP group and aescin group). The serum alanine aminotransferase (ALT), serum lactate dehydrogenase (LDH), hepatic cellular energy charge (EC) and adenosine triphosphate (ATP) were detected. The pathologic changes in pancreas and liver were also observed. Results The serum levels of ALT and LDH in aescin group were significantly lower than those of the AP group. The EC and ATP levels were significantly higher in aescin group than that of the AP group. Conclusion Introvenous injection of aescin can alleviate the liver injury in rats with acute pancreatitis. |
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| Keywords: | Pancreatitis Liver Aescin |
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