| 注射用头孢替唑钠与注射用卡络磺钠配伍稳定性考察 |
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| 引用本文： | 郑芳,李鹏,朱雪松,钟基大.注射用头孢替唑钠与注射用卡络磺钠配伍稳定性考察[J].实用药物与临床,2012,15(11):747-749. |
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| 作者姓名： | 郑芳 李鹏 朱雪松 钟基大 |
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| 作者单位： | 郑芳 (湖北医药学院附属东风医院药学部,湖北,十堰,442008) ； 李鹏 (湖北医药学院附属东风医院药学部,湖北,十堰,442008) ； 朱雪松 (湖北医药学院附属东风医院药学部,湖北,十堰,442008) ； 钟基大 (湖北医药学院附属东风医院感染科,湖北,十堰,442008) ； |
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| 摘 要： | 目的考察室温(20±1)℃]下,注射用头孢替唑钠与注射用卡络磺钠在0.9%氯化钠注射液中配伍的稳定性,为临床合理用药提供科学依据。方法采用反相高效液相色谱法测定配伍液中头孢替唑与卡络磺钠0～6 h内的含量变化,并观察配伍液的外观及pH值。结果注射用头孢替唑钠与注射用卡络磺钠6 h内配伍液外观、pH值及含量均无明显变化。结论在室温下,注射用头孢替唑钠与注射用卡络磺钠在0.9%氯化钠注射液中配伍6 h内可使用。
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| 关 键 词： | 头孢替唑 卡络磺钠 高效液相色谱法 配伍 稳定性 |
Compatible stability of ceftizole sodium for injection and carbazochrome sodium sulfonate for injection |
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| ZHENG Fanga,LI Penga,ZHU Xue-songa,ZHONG Ji-da.Compatible stability of ceftizole sodium for injection and carbazochrome sodium sulfonate for injection[J].Practical Pharmacy and Clinical Remedies,2012,15(11):747-749. |
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| Authors: | ZHENG Fanga LI Penga ZHU Xue-songa ZHONG Ji-da |
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| Institution: | b*(a.Department of Pharmacy,b.Department of Infection,Dongfeng Hospital,Hubei University of Medicine,Shiyan 442008,China) |
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| Abstract: | Objective To study the stability of ceftizole sodium for injection and carbazochrome sodium sulfonate for injection in 0.9% sodium chloride injection at room temperature(20±1)℃],in order to provide a scientific basis for rational drug use in clinical practice.Methods Changes in the contents of ceftizole sodium and carbazochrome sodium sulfonate were determined by RP-HPLC,and the changes of appearance,pH values were observed within 6 h.Results There was no significant change in the contents,appearance and pH values of the compatible solution at room temperature for 6 h.Conclusion The mixture of ceftizole sodium for injection and carbazochrome sodium sulfonate for injection in 0.9% sodium chloride injection can be used at room temperature within 6 h. |
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| Keywords: | Ceftizole Carbazochrome sodium sulfonate HPLC Compatibility Stability |
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