| 甘草甜素对接触性皮炎小鼠表皮内结合珠蛋白的影响 |
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| 引用本文： | 郭哲,高兴华,夏立新,王雅坤,马丽娟,何春涤,陈洪铎. 甘草甜素对接触性皮炎小鼠表皮内结合珠蛋白的影响[J]. 实用药物与临床, 2012, 15(11): 694-697 |
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| 作者姓名： | 郭哲 高兴华 夏立新 王雅坤 马丽娟 何春涤 陈洪铎 |
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| 作者单位： | 郭哲 (中国医科大学附属第一医院皮肤科,沈阳,110001) ； 高兴华 (中国医科大学附属第一医院皮肤科,沈阳,110001) ； 夏立新 (中国医科大学附属第一医院皮肤科,沈阳,110001) ； 王雅坤 (中国医科大学附属第一医院皮肤科,沈阳,110001) ； 马丽娟 (中国医科大学附属第一医院皮肤科,沈阳,110001) ； 何春涤 (中国医科大学附属第一医院皮肤科,沈阳,110001) ； 陈洪铎 (中国医科大学附属第一医院皮肤科,沈阳,110001) ； |
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| 基金项目： | 辽宁省教育厅创新团队科研基金,辽宁省科技厅科研基金 |
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| 摘 要： | 目的探讨甘草甜素对接触性皮炎小鼠表皮内结合珠蛋白的影响。方法 126只接触性皮炎小鼠分别给予生理盐水、不同剂量的甘草甜素及地塞米松。采用RT-PCR和原位杂交的方法检测接触性皮炎小鼠表皮内结合珠蛋白的表达。结果甘草甜素5 mg/kg和10 mg/kg组,激发后24和48 h表皮内结合珠蛋白表达增强,甘草甜素80 mg/kg组和地塞米松1 mg/kg组,激发后24和48 h表皮内结合珠蛋白表达减弱或消失。结论低剂量甘草甜素能增强接触性皮炎小鼠表皮内结合珠蛋白的表达,而高剂量甘草甜素则减弱结合珠蛋白的表达。
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| 关 键 词： | 甘草甜素 结合珠蛋白 接触性皮炎 |
Effect of glycyrrhizin on haptoglobin mRNA expression in mice epidermis of contact dermatitis |
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| GUO Zhe,GAO Xing-hua,XIA Li-xin,WANG Ya-kun,MA Li-juan,HE Chun-di,CHEN Hong-duo. Effect of glycyrrhizin on haptoglobin mRNA expression in mice epidermis of contact dermatitis[J]. Practical Pharmacy and Clinical Remedies, 2012, 15(11): 694-697 |
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| Authors: | GUO Zhe GAO Xing-hua XIA Li-xin WANG Ya-kun MA Li-juan HE Chun-di CHEN Hong-duo |
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| Affiliation: | *(Department of Dermatology,The First Hospital of China Medical University,Shenyang 110001,China) |
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| Abstract: | Objective To investigate the effect of glycyrrhizin(GL) on haptoglobin(Hp)mRNA expression in mice epidermis of contact dermatitis.Methods 126 mice of contact dermatitis were treated with normal saline,different doses of GL and dexamethasone respectively.The Hp mRNA expression was detected by RT-PCR and in situ hybridization.Results The expression of Hp mRNA in groups treated with GL 5 and 10 mg/kg were increased more significantly than those of normal saline at 24 and 48 h after challenging.The expression of Hp mRNA in groups treated with GL 80 mg/kg and dexamethasone 1 mg/kg were decreased more significantly than those of normal saline at 24 and 48 h after challenging.Conclusion The expression of Hp mRNA in mice epidermis of contact dermatitis can be regulated bidirectionally by GL.The expressions of Hp mRNA may be increased by lower dose,but decreased by higher dose of GL treatment. |
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| Keywords: | Glycyrrhizin(GL) Haptoglobin(Hp) Contact dermatitis |
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