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| 大鼠左全肺切除致右心室重塑的研究 | |
| 引用本文： | 罗锋,向小勇,赵兴吉.大鼠左全肺切除致右心室重塑的研究[J].第三军医大学学报,2010,32(15). |
| 作者姓名： | 罗锋 向小勇 赵兴吉 |
| 作者单位： | 1. 重庆市中山医院胸外科,重庆,400013 2. 重庆医科大学附属第一医院胸心外科,重庆,400042 3. 重庆市急救医疗中心胸心外科,重庆,400014 |
| 摘 要： | 目的 探讨大鼠左全肺切除术后余肺高血流量及缺氧是否导致肺动脉高压发生,进而导致右心室重塑,以及其可能的发生机制.方法 健康雄性SD大鼠24只,分为2组:实验组(n=12)大鼠行左全肺切除术,对照组(n=12)大鼠行假手术.术后饲养12周后用右心导管法测定平均肺动脉压(mPAP);检测大鼠动脉血氧分压;检测右心室肥大指数即右心室/(左心室+室间隔)right ventricle/left ventricle+septum, RV/(LV+S)]比值;光镜下观察及测量心肌细胞及小动脉形态学变化.结果 实验组大鼠mPAP及RV/(LV+S)明显高于对照组mPAP:(31.91±1.98) mmHg vs(17.82±1.94) mmHg, RV/(LV+S):(0.249±0.024) vs (0.225±0.015), P<0.01],血氧分压明显低于对照组(77.46±5.36)mmHg vs(90.39±6.02)mmHg,P<0.01],心肌细胞直径明显大于对照组(25.55±1.95)μm vs (15.55±1.75)μm,P<0.01],心肌小动脉管壁厚度占外径的百分率、心肌小动脉管壁面积占血管总面积的百分率均明显高于对照组(P<0.01);实验组大鼠RV/(LV+S)与mPAP呈正直线相关(r=0.879,P<0.01),mPAP与血氧分压呈负直线相关(r=-0.862,P<0.01).结论 大鼠左全肺切除术后余肺高血流量及缺氧可使肺动脉压力升高,进而导致心肌小动脉增生、右心室肥大. |
| 关 键 词： | 心室重塑 血管重塑 肺动脉高压 全肺切除术 大鼠 |
Right ventricular remodeling induced by left total pneumonectomy in rats |
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| Luo Feng,Xiang Xiaoyong,Zhao Xingji.Right ventricular remodeling induced by left total pneumonectomy in rats[J].Acta Academiae Medicinae Militaris Tertiae,2010,32(15). | |
| Authors: | Luo Feng Xiang Xiaoyong Zhao Xingji |
| Institution: | Luo Feng1,Xiang Xiaoyong2,Zhao Xingji3(1Department of Thoracic Surgery,Chongqing Zhongshan Hospital,Chongqing,400013,2Department of Thoracic and Cardiac Surgery,First Affiliated Hospital,Chongqing Medical University,400042,3Department of Thoracic and Cardiac Surgery,Chongqing First Aid Medical Center,400014,China) |
| Abstract: | Objective To study the effect of high pulmonary blood flow and hypoxia in right ventricular remodeling induced by left total pneumonectomy in rats and its mechanism.Methods Twenty-four male SD rats were randomly divided into experimental group(left pneumonectomy,n=12) and control group(sham operation,n=12).After 12 weeks of feeding,mean pulmonary arterial pressure(mPAP) of each rat was evaluated using a right cardiac catheterization procedure.Partial artery oxygen pressure was measured.The Ratio of Right ve... |
| Keywords: | ventricular remodeling vascular remodeling pulmonary hypertension pneumonectomy rats |
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