| 脓毒症患者血清脂联素水平的初步研究 |
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| 引用本文： | 吴艳春,黄立权,王灵聪,智屹惠,雷澍,江荣林.脓毒症患者血清脂联素水平的初步研究[J].中华危重症医学杂志（电子版）,2010,3(5):5-7. |
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| 作者姓名： | 吴艳春 黄立权 王灵聪 智屹惠 雷澍 江荣林 |
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| 作者单位： | 浙江中医药大学附属第一医院ICU,杭州,310006 |
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| 基金项目： | 浙江省中医药科技项目(2009YA009) |
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| 摘 要： | 目的探讨脓毒症患者中血清脂联素水平的变化及其与胰岛素抵抗（IR）、C反应蛋白（CRP）之间的关系。方法选取本院ICU脓毒症患者45例和健康对照20例，患者被诊断为脓毒症后的第1、5和10d抽取空腹静脉血检测空腹血糖（FBG）、空腹胰岛素（FINS）、CRP、脂联素浓度，使用稳态模式法（HOMA）计算胰岛素抵抗指数（HOMA—IR）。结果脓毒症组第1、5和10d的血清脂联素浓度分别为（4．82±3．29）、（5．15±3．41）、（4．97±3．21）μg／ml，均明显低于对照组（8．81±2．70）μg／ml（P均〈0．01）。脓毒症组各时间点血清脂联素浓度比较，差异无统计学意义（P〉0．05）。脓毒症组血清脂联素与BMI、FBG、FINS、HOMA—IR、急性生理学与慢性健康状况评分系统（APACHE）II评分均存在显著负相关，与CRP无显著相关。结论脓毒症患者血清脂联素水平下降，且与HOMA—IR及APACHEⅡ评分均存在显著负相关。
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| 关 键 词： | 脓毒症 脂联素 胰岛素抵抗 |
Preliminary study on changes of serum adiponectin concentrations in patients with sepsis |
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| WU Yan-chun,HUANG Li-quan,WANG Ling-cong,ZHI Yi-hui,LEI Shu,JIANG Rong-lin.Preliminary study on changes of serum adiponectin concentrations in patients with sepsis[J].Chinese Journal of Critical Care Medicine ( Electronic Editon),2010,3(5):5-7. |
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| Authors: | WU Yan-chun HUANG Li-quan WANG Ling-cong ZHI Yi-hui LEI Shu JIANG Rong-lin |
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| Institution: | WU Yan-chun,HUANG Li-quan,WANG Ling-cong,ZHI Yi-hui,LEI Shu,JIANG Rong-lin.Department of Intensive Care Unite,the First Affiliated Hospital of Zhejiang Chinese Medical University,Hangzhou 310006,China |
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| Abstract: | Objective To explore the changes of serum adiponectin in septic patients,and the relations between adiponectin and insulin resistance (IR),C-reactive protein (CRP).Methods Forty-five septic patients and 20 healthy controls subjects were enrolled.Fasting blood glucose (FBG),fasting insulin (FINS),CRP and adiponectin were determined on the 1st,5th and 10th d after diagnosed as sepsis among patients.Insulin resistance (IR) index was estimated by homeostasis model assessment (HOMA).Results The mean serum adipon... |
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| Keywords: | Sepsis Adiponectin Insulin resistance |
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