HLA-G在子宫内膜异位症中的表达及意义

目的:研究人类白细胞抗原-G(HLA-G)在子宫内膜异位症患者在位和异位内膜组织中的表达,探讨HLA-G分子在内异症发生发展中的作用.方法:采用链霉素抗生物素蛋白-过氧化物酶(S-P)法检测子宫内膜异位症患者19例在位子宫内膜和30例异位内膜中HLA-G分子的表达水平,以30例非子宫内膜异位症患者的子宫内膜作为对照.结果:内异症在位子宫内膜和异位内膜HLA-G的阳性表达率(42%,53%)均显著性高于对照组正常子宫内膜(P＜0.01),但在内异症在位内膜和异位内膜之间HLA-G的阳性表达率无显著性差异(P＞0.05).结论:异常表达的HLA-G分子可能在内异症的发生发展过程中发挥着作用.

Expression of HLA-G in endometriosis and its significance

AIM: To detect the expression of human leukocyte antigen-G (HLA-G) in eutopic and ectopic endometrium in patients with endometriosis,thereby to determine the role of HLA-G in the pathogenesis of endometriosis. METHODS: The expression of HLA-G protein in 19 eutopic endometria and 30 ectopic endometria of patients with endometriosis was analyzed immunohistochemically by streptavidin-peroxidase (S-P) method. The endometria of 30 patients without endometriosis were studied as controls. RESULTS: Positive rates of HLA-G in eutopic and ectopic endometriotic tissues were significantly higher than that in the normal endometrium (P<0.01). In eutopic and ectopic endometrium of endometriosis,the positive rates of HLA-G were 42% and 53%, respectively. There was no significant difference in the positive rate of HLA-G between eutopic and ectopic endometriotic tissues (P>0.05). CONCLUSION: The abnormal expression of HLA-G protein in endometriotic tissue may play a role in the pathogenesis of endometriosis.