| 大鼠肾皮质细胞浆脂质过氧化与庆大霉素肾毒性关系的研究 |
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| 引用本文： | 程益民,刘钟明,李红,李鲁琴,刘章锁,赵根尚.大鼠肾皮质细胞浆脂质过氧化与庆大霉素肾毒性关系的研究[J].郑州大学学报(医学版),1993(2). |
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| 作者姓名： | 程益民 刘钟明 李红 李鲁琴 刘章锁 赵根尚 |
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| 作者单位： | 河南医科大学第一附属医院内科
(程益民，刘钟明，李红，李鲁琴，刘章锁)，河南医科大学第二附属医院胸外科(赵根尚) |
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| 摘 要： | 通过测定大鼠肾皮质细胞浆超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶活性(G-Px)及丙二醛(MDA)含量,观察肾皮质超微结构变化。发现庆大霉素可抑制肾皮质细胞浆SOD、G-Px活性,使MDA含量升高,同时出现形态学及肾功能损伤。人参总皂甙可保护SOD、G-Px活性,降低MDA含量,同时预防形态学及肾功能损害。实验表明,庆大霉素可通过抑制胞浆SOD活性、G-Px活性,使胞浆脂质过氧化程度增加,后者通过细胞毒作用导致肾功能损害。
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| 关 键 词： | 庆大霉素 脂质过氧化 人参皂甙 细胞浆 肾 毒性 大鼠 |
Relation between Lipid Peroxidation(LPO)in Renal Cortical Cytoplasm(RCC)And Gentamycin Nephrotoxicity |
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| Cheng Yimin,Liu Zhongming,Li Hong,Li Luqing,Liu Zhuangshuo,Zhao Genshang.Relation between Lipid Peroxidation(LPO)in Renal Cortical Cytoplasm(RCC)And Gentamycin Nephrotoxicity[J].Journal of Zhengzhou University: Med Sci,1993(2). |
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| Authors: | Cheng Yimin Liu Zhongming Li Hong Li Luqing Liu Zhuangshuo Zhao Genshang |
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| Institution: | Cheng Yimin,Liu Zhongming,Li Hong,Li Luqing,Liu Zhuangshuo,Zhao Genshang Department of Internal Medicine,the First Affiliated Hospital |
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| Abstract: | Superoxide dismutase (SOD) activity, glutathione peroxidase (G-Px) activity, andmalondialdehyde (MDA)level in RCC in rats were measured,and the renal cortical ultra-structure wasobserved. The results showed that gentamycin could inhibit SOD and G-Px activities,and increase theMDA levels in RCC. There were morphologic changes and renal dysfunction simultaneously.Ginsenosides was able to protect the SOD and G-Px activities, and decrease the MDA levels. At thesame time, the morphologic changes and the impairment of renal function were prevented. The datasuggested that gentamycin might increase LPO levels in RCC because of the inhibition of SOD and G-Px activities in RCC,and give rise to renal dysfunction by cytotoxic reaction. |
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| Keywords: | Gentamicin Lipid Peroxidation Ginsenosides Cytoplasm |
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