| 国产长春瑞滨联合顺铂治疗晚期非小细胞肺癌的临床观察 |
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| 引用本文： | 马锐,伞宝君. 国产长春瑞滨联合顺铂治疗晚期非小细胞肺癌的临床观察[J]. 临床肿瘤学杂志, 2003, 8(4): 296-297 |
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| 作者姓名： | 马锐 伞宝君 |
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| 作者单位： | 110042,沈阳,辽宁省肿瘤医院内二科 |
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| 摘 要： | 目的：观察抗肿瘤新药国产长春瑞滨(NVB盖诺)加顺铂(DDP)联合化疗治疗晚期非小细胞肺癌(NSCLC)的疗效。方法：治疗NSCLC48例。男性34例，女性14例。病理类型以腺癌为主(28例)。结果：部分缓解(PR)21例，稳定(NC)24例，进展(PD)3例，总有效率47．92％。盖诺的剂量限制毒性为骨髓抑制，白细胞下降占81．25％。局部疼痛或静脉炎发生率29．17％。结论：以盖诺为主联合化疗治疗晚期NSCLC的有效率高，毒性可以耐受，是一个有前途的抗肿瘤新药。
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| 关 键 词： | 长春瑞滨 顺铂 联合治疗 晚期非小细胞肺癌 临床观察 化疗 疗效 |
| 文章编号： | 1009-0460(2003)04-0296-02 |
| 修稿时间： | 2002-05-28 |
Homemade Vinorelbine based combination chemotherapy in non-small cell lung cancer |
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| MA Rui,SAN Bao-jun. Homemade Vinorelbine based combination chemotherapy in non-small cell lung cancer[J]. Chinese Clinical Oncology, 2003, 8(4): 296-297 |
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| Authors: | MA Rui SAN Bao-jun |
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| Affiliation: | MA Rui,SAN Bao-jun.Department of Medical Oncology Liaoning Province Tumor Hospital,Shenyang 110042 |
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| Abstract: | Objective:To evaluate the results of combination chemotherapy with vinorelbine(VNLB) plus cisplatin (DDP) in the treatment of non-small cell lung cancer(NSCLC).Methods:Forty-eight patients with advanced NSCLC were enrolled in this study.Adenocarcinoma was the most common type of malignancy.Results:The overall rate was 47.92%.The dose limiting toxicity was neutropenia which was seen 81.25% in treated cases.The local venous toxicity was observed in 29.17% of the patients.Conclusion:A high response rate was obtained in advanced NSCLC treated by NVB plus DDP.NVB is a promising antitumor agent with tolerable toxicity. |
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| Keywords: | Non-small-cell lung cancer Chemotherapy Vinorelbin Cisplatin |
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