Imaging of serotonin and dopamine transporters in the living human brain |
| |
Authors: | Jyrki T Kuikka Jari Tiihonen Kim A Bergström Jari Karhu Päivi Hartikainen Heimo Viinamäki Esko Länsimies Johannes Lehtonen Panu Hakola |
| |
Institution: | (1) Department of Clinical Physiology, Kuopio University Hospital, FIN-70210 Kuopio, Finland;(2) Department of Forensic Psychiatry, Kuopio University Hospital, FIN-70210 Kuopio, Finland;(3) Department of Clinical Neurophysiology, Kuopio University Hospital, FIN-70210 Kuopio, Finland;(4) Department of Neurology, Kuopio University Hospital, FIN-70210 Kuopio, Finland;(5) Department of Psychiatry, Kuopio University Hospital, FIN-70210 Kuopio, Finland |
| |
Abstract: | Alterations in brain serotonin (5-HT) and dopamine (DA) activity are associated with several neuropsychiatric disorders, but until now it has not been possible to simultaneously visualize or quantify the 5-HT and the DA transporter density in the living human brain. In this paper we report on the imaging of 5-HT and DA transporters in 28 healthy controls with single-photon emission tomography using iodine-123 labelled 2 -carbomethoxy-3 -(4-iodophenyl)tropane (123I] -CIT) as the tracer. The 123I] -CIT distribution showed the most prominent 5-HT activity in the medial frontal cortex, hypothalamus, midbrain and occipital cortex and the greatest DA activity in the basal ganglia. The specific binding of the 5-HT transporters in the medial frontal cortex was 0.377±0.031 and that of the DA transporters in the basal ganglia, 0.916±0.007. Gjedde-Patlak plots indicated two separate components: the first was assumed to represent 5-HT transporters with a slope of 1.29±0.27 h–1 and the second, DA transporters with a slope of 0.30±0.04 h–1. This distinct kinetic pattern and the fact that 5-HT and DA transporters are situated in different parts of the brain provides an opportunity to study in vivo patients suffering from various neuropsychiatric disorders. |
| |
Keywords: | 2 -Carbomethoxy-3 gif" alt="beta" align="MIDDLE" BORDER="0">-Carbomethoxy-3 -(4-iodophenyl)tropane" target="_blank">gif" alt="beta" align="MIDDLE" BORDER="0">-(4-iodophenyl)tropane Iodine-123 Dopamine Receptor Serotonin |
本文献已被 SpringerLink 等数据库收录! |
|