口服钙片对试验人群血压水平的影响

目的 评价口服乳酸钙片后对血压水平的作用以及对血清中主要元素如钠、钾、钙、磷的影响。方法 对山西某一低钙、高盐膳食及血压均值、患病率较高的农村自然人群,在人群血压筛查的基础上,从３０～６４岁志愿选出１１２名,采用随机双盲对照的方法,分别服用酸钙片（每日补钙８００ｍｇ）安慰剂,观察５周后进行有关复查。其中９８名志愿完成了试验（男３９人,女５９人）。结果 口服３５ｄ钙片后与安慰剂组比较,收缩压净下

Effects of oral calcium supplementation on blood pressure in population

Objective To assess the effects of oral intake of calcium lactate tablet on blood pressure and serum levels of sodium, potassium, calcium and phosphors. Methods In a rural area with natural population with higher average blood pressure and prevalence of hypertension, and with high salt and low calcium intake in diet in Yu County, Shanxi Province, 112 volunteers aged 30 to 64 years were selected based on a mass screening for hypertension, and randomized into trial and control groups with double blinding, taking calcium lactate tablets (800 mg of calcium daily) and placebo respectively for five weeks. Ninety eight of them complied with the medical order completely, 39 males and 59 females, and were followed up for systolic (SBP) and diastolic blood pressure (DBP), and their fasting venous blood specimen and 8 hour nocturnal urine specimens were collected. Twenty four hour diet recall was obtained for three consecutive days from all of them. Results Reduction of 4 7 mm Hg (0 62 kPa) and 2 7 mm Hg (0 36 kPa) in systolic and diastolic blood pressure, respectively in the trial group was observed, as compared with that in control one, with P values of 0 027 and 0 074, respectively, after 35 days of treatment. The higher their baseline BP level, the greater reduction of their BP after treatment. Urinary excretion of calcium increased and serum level of phosphorus reduced after oral administration of calcium. Conclusion In an area with higher prevalence of hypertension and with high salt and low calcium intake in diet, change in diet composition or supplementation with calcium could reduce their average blood pressure and prevent them from hypertension for those with mild and moderate hypertension and in high risk with higher blood pressure.