Serum sialyl-Tn antigen in colorectal cancer and its relationship to prognosis] |
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| Authors: | A Yamaguchi Y Tukioka S Fushida Y Kurosaka M Kanno Y Yonemura K Miwa I Miyazaki |
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| Institution: | Dept. of Surgery II, School of Medicine, Kanazawa University, Japan. |
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| Abstract: | Serum sialyl-Tn antigen level was studied in 117 cases of colorectal cancer. The positive rates for serum sialyl-Tn antigen were 23.1% in primary colorectal cancer. There is a significant correlation between the positive rates of serum sialyl-Tn antigen and liver metastases, peritoneal dissemination, or lymph node metastases. The survival rate for patients with sialyl-Tn antigen positive sera was lower than those with sialyl-Tn antigen negative. Among patients who underwent curative operation, patients with sialyl-Tn positive sera gave a recurrence rate of 35.7%, while those with sialyl-Tn negative sera recorded a recurrence rate of 14.7%. There is no correlation between the positive rates of serum sialyl-Tn antigen and DNA ploidy pattern. Serum sialyl-Tn antigen levels may be a useful indicator in projecting the prognosis of colorectal cancer. |
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